| Title: | "Bioactive molecules from ciliates: Structure, activity, and applicative potential" |
| Author(s): | Alimenti C; Buonanno F; Di Giuseppe G; Guella G; Luporini P; Ortenzi C; Vallesi A; |
| Address: | "Laboratory of Eukaryotic Microbiology and Animal Biology, School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy. Laboratory of Protistology and Biology Education, Department of Education, Cultural Heritage, and Tourism (ECHT), Universita degli Studi di Macerata, Macerata, Italy. Unit of Protistology, Department of Biology, University of Pisa, Pisa, Italy. MARinePHARMA Center, University of Pisa, Pisa, Italy. Bioorganic Chemistry Lab, Department of Physics, University of Trento, Trento, Italy" |
| ISSN/ISBN: | 1550-7408 (Electronic) 1066-5234 (Print) 1066-5234 (Linking) |
| Abstract: | "Ciliates are a rich source of molecules synthesized to socialize, compete ecologically, and interact with prey and predators. Their isolation from laboratory cultures is often straightforward, permitting the study of their mechanisms of action and their assessment for applied research. This review focuses on three classes of these bioactive molecules: (i) water-borne, cysteine-rich proteins that are used as signaling pheromones in self/nonself recognition phenomena; (ii) cell membrane-associated lipophilic terpenoids that are used in interspecies competitions for habitat colonization; (iii) cortical granule-associated molecules of various chemical nature that primarily serve offence/defense functions" |
| Keywords: | Cell Communication *Ciliophora/metabolism Ecosystem Pheromones Signal Transduction climacostol euplotins resorcinol signaling proteins terpenoids; |
| Notes: | "MedlineAlimenti, Claudio Buonanno, Federico Di Giuseppe, Graziano Guella, Graziano Luporini, Pierangelo Ortenzi, Claudio Vallesi, Adriana eng UniversitA degli Studi di Camerino/ Research Support, Non-U.S. Gov't Review 2022/01/12 J Eukaryot Microbiol. 2022 Sep; 69(5):e12887. doi: 10.1111/jeu.12887. Epub 2022 Jan 28" |
