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J Microencapsul

Title:		Essential oil from Zanthoxylum tingoassuiba loaded into multilamellar liposomes useful as antimicrobial agents
Author(s):		Detoni CB; Cabral-Albuquerque EC; Hohlemweger SV; Sampaio C; Barros TF; Velozo ES;
Address:		"Laboratorio de Pesquisa em Materia Medica, Universidade Federal da Bahia, Faculdade de Farmacia, 40170-290 Ondina, Salvador/Ba, Brazil"
Journal Title:		J Microencapsul
Year:		2009
Volume:		26
Issue:		8
Page Number:		684 - 691
DOI:		10.1080/02652040802661887
ISSN/ISBN:		1464-5246 (Electronic) 0265-2048 (Linking)
Abstract:		"Zanthoxylum tingoassuiba essential oil (EO) is a complex mixture of organic compounds among which methyl-N-methylanthranilate and sesquiterpene alcohol alpha-bisabolol represent the main compounds. The essential oil antimicrobial activity was studied against bacteria and fungi cells by diffusion disk method and significant activity was observed against S. aureus, S. aureus isolated multi-resistant and the dermathophyte fungi. Essential oil from Zanthoxylum tingoassuiba loaded into DPPC multilamellar liposomes (MLV) was successfully produced through a thin film hydration method with mean diameter of 9.37 +/- 4.69 microm. The EO-loaded liposomes showed adequate sphericity and narrower size distribution than empty liposomes. Results also showed that Zanthoxylum tingoassuiba essential oil can be incorporated in appreciable amounts (43.7 +/- 6.0%) in the prepared vesicular dispersions. A strong interaction between essential oil and lipid bilayer was indicated by a significant decrease in T(m) of the EO-loaded liposomes related to empty vesicles. Essential oil showed incomplete release profile from liposomes, suggesting that EO-loaded liposomes will be useful in pharmaceutical applications to enhance essential oil targeting to cells"
Keywords:		"1, 2-Dipalmitoylphosphatidylcholine Anti-Infective Agents/*administration & dosage Drug Carriers/*chemistry Liposomes/*chemistry Oils, Volatile/*administration & dosage/pharmacology Staphylococcaceae/drug effects Zanthoxylum/*chemistry;"
Notes:		"MedlineDetoni, C B Cabral-Albuquerque, E C M Hohlemweger, S V A Sampaio, C Barros, T F Velozo, E S eng Research Support, Non-U.S. Gov't England 2009/11/06 J Microencapsul. 2009 Dec; 26(8):684-91. doi: 10.1080/02652040802661887"