| Title: | Functional analysis of the guanylyl cyclase type D signaling system in the olfactory epithelium |
| Author(s): | Cockerham RE; Leinders-Zufall T; Munger SD; Zufall F; |
| Address: | "Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA" |
| DOI: | 10.1111/j.1749-6632.2009.04104.x |
| ISSN/ISBN: | 1749-6632 (Electronic) 0077-8923 (Print) 0077-8923 (Linking) |
| Abstract: | "The mammalian olfactory system recognizes a wide range of chemical stimuli. The majority of cells in the main olfactory epithelium (MOE) use a cAMP-mediated signaling system to transduce odor signals. However, a subset of MOE neurons instead expresses components of a cGMP signaling cascade, including the receptor guanylyl cyclase GC-D and the cyclic nucleotide-gated channel subunit CNGA3. We used a combination of molecular biological, physiological, and imaging approaches to characterize this neuronal population. Neurons expressing GC-D show excitatory responses to the natriuretic peptide hormones uroguanylin and guanylin, as well as to stimuli present in urine, that are dependent on both GC-D and CNGA3. Though all GC-D-expressing neurons are highly sensitive to these stimuli, individual cells are differentially tuned to either one or both of the peptides. Together, these findings suggest that neurons expressing GC-D are part of a specialized olfactory subsystem that is responsive to semiochemicals" |
| Keywords: | "Animals Guanylate Cyclase/genetics/*metabolism Mice Mice, Knockout Olfactory Mucosa/*enzymology *Signal Transduction;" |
| Notes: | "MedlineCockerham, Renee E Leinders-Zufall, Trese Munger, Steven D Zufall, Frank eng R01 DC005633/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2009/08/19 Ann N Y Acad Sci. 2009 Jul; 1170:173-6. doi: 10.1111/j.1749-6632.2009.04104.x" |
