| Title: | "Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons" |
| Author(s): | Cloutier JF; Giger RJ; Koentges G; Dulac C; Kolodkin AL; Ginty DD; |
| Address: | "Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA" |
| DOI: | 10.1016/s0896-6273(02)00635-9 |
| ISSN/ISBN: | 0896-6273 (Print) 0896-6273 (Linking) |
| Abstract: | "The mechanisms that underlie axonal pathfinding of vomeronasal neurons from the vomeronasal organ (VNO) in the periphery to select glomeruli in the accessory olfactory bulb (AOB) are not well understood. Neuropilin-2, a receptor for secreted semaphorins, is expressed in V1R- and V3R-expressing, but not V2R-expressing, postnatal vomeronasal neurons. Analysis of the vomeronasal nerve in neuropilin-2 (npn-2) mutant mice reveals pathfinding defects at multiple choice points. Vomeronasal sensory axons are severely defasciculated and a subset innervates the main olfactory bulb (MOB). While most axons of V1R-expressing neurons reach the AOB and converge into distinct glomeruli in stereotypic locations, they are no longer restricted to their normal anterior AOB target zone. Thus, Npn-2 and candidate pheromone receptors play distinct and complementary roles in promoting the wiring and patterning of sensory neurons in the accessory olfactory system" |
| Keywords: | "Animals Axons/*metabolism Embryo, Mammalian/anatomy & histology/physiology In Situ Hybridization Ligands Membrane Glycoproteins/genetics/metabolism Membrane Proteins/genetics/metabolism Mice Mice, Transgenic Nerve Growth Factors/metabolism Nerve Tissue Pr;neuroscience;" |
| Notes: | "MedlineCloutier, Jean Francois Giger, Roman J Koentges, Georgy Dulac, Catherine Kolodkin, Alex L Ginty, David D eng R01MH59199/MH/NIMH NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 2002/03/22 Neuron. 2002 Mar 14; 33(6):877-92. doi: 10.1016/s0896-6273(02)00635-9" |
