| Title: | Sensory neurons expressing the atypical olfactory receptor guanylyl cyclase D are required for the acquisition of odor preferences by mice in diverse social contexts |
| Author(s): | Zimmerman AD; Nagy CR; Munger SD; |
| Address: | "Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, United States; Center for Smell and Taste, University of Florida, Gainesville, FL 32610, United States; Training Program in Chemosensory Science, University of Florida, Gainesville, FL 32610, United States. Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, United States; Center for Smell and Taste, University of Florida, Gainesville, FL 32610, United States. Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, United States; Center for Smell and Taste, University of Florida, Gainesville, FL 32610, United States; Training Program in Chemosensory Science, University of Florida, Gainesville, FL 32610, United States; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Florida College of Medicine, Gainesville, FL 32610, United States. Electronic address: steven.munger@ufl.edu" |
| DOI: | 10.1016/j.physbeh.2020.113150 |
| ISSN/ISBN: | 1873-507X (Electronic) 0031-9384 (Print) 0031-9384 (Linking) |
| Abstract: | "Animals use social communication to learn important information from conspecifics that can guide appropriate behavioral choices. For example, during the social transmission of food preference (STFP), conspecific semiochemicals detected by mouse olfactory sensory neurons (OSNs) expressing the atypical olfactory receptor guanylyl cyclase D (GC-D+ OSNs) promote the acquisition of food preferences in the recipient animal, mitigating the risk of ingesting food contaminated with toxins or pathogens. However, it is unclear if GC-D+ OSNs mediate preference learning outside this specific context. Here, we report that GC-D+ OSNs are required for the acquisition of odor preferences by both adult and juvenile mice, and that GC-DD-dependent preference could be formed for conditionally aversive odors. We used a two-choice olfactory behavioral test to assess odor preferences in adult Gucy2d +/+, +/- and -/- mice that encountered novel odors together with GC-D+ OSN stimuli (guanylin family peptides), during social investigation of a live conspecific, or during suckling as pups. Gucy2d +/+ and +/- mice (which express functional GC-D), but not Gucy2d -/- littermates, successfully acquire a preference for the demonstrated odor in any of these behavioral paradigms. Mice could even acquire a GC-D-dependent preference for odors to which they had recently formed a conditioned aversion. Together, these results demonstrate that GC-D+ OSNs mediate the acquisition of socially-transmitted odor preferences in different social and experiential contexts and at different life stages" |
| Keywords: | "Animals Guanylate Cyclase Mice Odorants *Olfactory Receptor Neurons Receptors, Cell Surface *Receptors, Odorant Smell Social Environment Conditioned aversion Learning Olfaction Social transmission of food preference Uroguanylin;" |
| Notes: | "MedlineZimmerman, Arthur D Nagy, Christina R Munger, Steven D eng R01 DC005633/DC/NIDCD NIH HHS/ T32 DC015994/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural 2020/08/26 Physiol Behav. 2020 Dec 1; 227:113150. doi: 10.1016/j.physbeh.2020.113150. Epub 2020 Aug 23" |
