| Title: | Review of recent developments in determining volatile organic compounds in exhaled breath as biomarkers for lung cancer diagnosis |
| Author(s): | Zhou J; Huang ZA; Kumar U; Chen DDY; |
| Address: | "Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada. Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada. Electronic address: chen@chem.ubc.ca" |
| DOI: | 10.1016/j.aca.2017.09.021 |
| ISSN/ISBN: | 1873-4324 (Electronic) 0003-2670 (Linking) |
| Abstract: | "Lung cancer is the most common cause of cancer deaths, its global incidence is rising, and continuing rises are predicted. The potential to diagnose lung cancers based on the determination of volatile organic compounds (VOCs) in human breath has been attracting increasing attention with the development of new techniques and methodologies. However, despite many reports of VOC profiling in lung cancer patients, little is known about how specific biomarkers relate to the biochemical pathways involved in lung cancer development, and there is still no reliable method for diagnosing lung cancer at the early stages. This review summarizes some of the latest methods used for monitoring biomarkers in lung cancer patients, which could be applicable for clinical diagnosis. Techniques for capturing and pre-concentrating biomarkers, and the technologies used for subsequently determining them, are also discussed" |
| Keywords: | "Biomarkers, Tumor/*analysis Breath Tests *Exhalation Humans Lung Neoplasms/*diagnosis Volatile Organic Compounds/*analysis Biomarker Early diagnosis Exhaled breath Lung cancer Volatile organic compounds;" |
| Notes: | "MedlineZhou, Jiemin Huang, Zi-Ao Kumar, Ujendra Chen, David D Y eng Review Netherlands 2017/11/16 Anal Chim Acta. 2017 Dec 15; 996:1-9. doi: 10.1016/j.aca.2017.09.021. Epub 2017 Sep 13" |
