| Title: | Subchronic and mild social defeat stress downregulates peripheral expression of sweet and umami taste receptors in male mice |
| Author(s): | Yoshida Y; Miyazaki M; Yajima Y; Toyoda A; |
| Address: | "Department of Food and Life Sciences, College of Agriculture, Ibaraki University, Ami, Ibaraki, 300-0393, Japan. Department of Food and Life Sciences, College of Agriculture, Ibaraki University, Ami, Ibaraki, 300-0393, Japan; United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu-city, Tokyo, 183-8538, Japan. Electronic address: atsushi.toyoda.0516@vc.ibaraki.ac.jp" |
| Journal Title: | Biochem Biophys Res Commun |
| DOI: | 10.1016/j.bbrc.2021.09.063 |
| ISSN/ISBN: | 1090-2104 (Electronic) 0006-291X (Linking) |
| Abstract: | "Depression is associated with taste disorders; however, the mechanisms by which mental stress affects taste perception are not well understood. This study aimed to elucidate the effects of psychosocial stress on peripheral taste-sensing systems using a mouse depression model. Male mice were subjected to subchronic and mild social defeat stress (sCSDS). Results showed that sCSDS significantly increased body weight, food and water intake, and social avoidance behavior and that sCSDS did not change reward-seeking behavior on sucrose preference but tended to decrease pheromonal preference for female urine. Furthermore, sCSDS downregulated the mRNA levels of sweet and umami taste receptor subunits, i.e., sweet taste receptor type 1 members 2 and 3 (T1R2 and T1R3), but not the umami taste receptor subunit, i.e., taste receptor type 1 member 1 (T1R1), in the circumvallate papillae of mice. It is known that sucrose preference is mediated by the gut-brain axis without taste perception; thus, it was considered that sCSDS affected the peripheral taste-sensing systems, rather than the central reward systems, which mediate sucrose preference. This is the first study to report that psychosocial stress affects peripheral sweet and umami taste-sensing systems" |
| Keywords: | "Anhedonia Animals Behavior, Animal Body Weight Brain-Gut Axis/physiology Depression/metabolism Drinking Eating *Gene Expression Regulation Male Mice Mice, Inbred C57BL Mice, Inbred ICR Receptors, G-Protein-Coupled/metabolism Reward *Social Behavior *Socia;" |
| Notes: | "MedlineYoshida, Yuta Miyazaki, Misa Yajima, Yuhei Toyoda, Atsushi eng Research Support, Non-U.S. Gov't 2021/10/02 Biochem Biophys Res Commun. 2021 Nov 19; 579:116-121. doi: 10.1016/j.bbrc.2021.09.063. Epub 2021 Sep 24" |
