| Title: | Volatile Organic Compounds as Potential Biomarkers for Noninvasive Disease Detection by Nanosensors: A Comprehensive Review |
| Author(s): | Velusamy P; Su CH; Ramasamy P; Arun V; Rajnish N; Raman P; Baskaralingam V; Senthil Kumar SM; Gopinath SCB; |
| Address: | "Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath Institute of Higher Education and Research (BIHER), Chennai, Tamil Nadu, India. Department of Chemical Engineering, Ming Chi University of Technology, Taishan, Taipei, Taiwan. Department of Biotechnology SRFBMST, Sri Ramachandra Institute of Higher Education & Research, Chennai, Tamil Nadu, India. Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India. Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechnology in Animal Health Lab, Department of Animal Health and Management, Alagappa University, Karaikudi, Tamil Nadu, India. Electroorganic and Materials Electrochemistry Division, CSIR-Central Electrochemical Research Institute, Karaikudi, Tamil Nadu, India. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. Faculty of Chemical Engineering Technology and Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, Arau, Perlis, Malaysia. Centre of Excellence for Nanobiotechnology and Nanomedicine (CoExNano), Faculty of Applied Sciences, AIMST University, Semeling, Kedah, Malaysia" |
| DOI: | 10.1080/10408347.2022.2043145 |
| ISSN/ISBN: | 1547-6510 (Electronic) 1040-8347 (Linking) |
| Abstract: | "Biomarkers are biological molecules associated with physiological changes of the body and aids in the detecting the onset of disease in patients. There is an urgent need for self-monitoring and early detection of cardiovascular and other health complications. Several blood-based biomarkers have been well established in diagnosis and monitoring the onset of diseases. However, the detection level of biomarkers in bed-side analysis is difficult and complications arise due to the endothelial dysfunction. Currently single volatile organic compounds (VOCs) based sensors are available for the detection of human diseases and no dedicated nanosensor is available for the elderly. Moreover, accuracy of the sensors based on a single analyte is limited. Hence, breath analysis has received enormous attention in healthcare due to its relatively inexpensive, rapid, and noninvasive methods for detecting diseases. This review gives a detailed analysis of how biomarker imprinted nanosensor can be used as a noninvasive method for detecting VOC to health issues early using exhaled breath analysis" |
| Keywords: | Array-technology breath analyzer health complications nanosensor organic molecule; |
| Notes: | "PublisherVelusamy, Palaniyandi Su, Chia-Hung Ramasamy, Palaniappan Arun, Viswanathan Rajnish, Narayanan Raman, Pachaiappan Baskaralingam, Vaseeharan Senthil Kumar, Sakkarapalayam Murugesan Gopinath, Subash C B eng Review 2022/02/25 Crit Rev Anal Chem. 2022 Feb 24:1-12. doi: 10.1080/10408347.2022.2043145" |
