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Molecules

Title:		"Phytochemical Profile and Anticancer Potential of Endophytic Microorganisms from Liverwort Species, Marchantia polymorpha L"
Author(s):		Stelmasiewicz M; Swiatek L; Ludwiczuk A;
Address:		"Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, Poland. Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland"
Journal Title:		Molecules
Year:		2021
Volume:		20211228
Issue:		1
Page Number:		-
DOI:		10.3390/molecules27010153
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Liverwort endophytes could be a source of new biologically active substances, especially when these spore-forming plants are known to produce compounds that are not found in other living organisms. Despite the significant development of plant endophytes research, there are only a few studies describing liverwort endophytic microorganisms and their metabolites. In the presented study, the analysis of the volatile compounds obtained from thallose liverwort species, Marchantia polymorpha L., and its endophytes was carried out. For this purpose, non-polar extracts of plant material and symbiotic microorganisms were obtained. The extracts were analyzed using gas chromatography coupled to mass spectrometry. Compounds with the structure of diketopiperazine in the endophyte extract were identified. Liverwort volatile extract was a rich source of cuparane-, chamigrane-, acorane-, and thujopsane-type sesquiterpenoids. The cytotoxicity of ethyl acetate extracts from endophytic microorganisms was evaluated on a panel of cancer (FaDu, HeLa, and SCC-25) cell lines and normal (VERO), and revealed significant anticancer potential towards hypopharyngeal squamous cell carcinoma and cervical adenocarcinoma"
Keywords:		"Animals Antineoplastic Agents, Phytogenic/*chemistry/*pharmacology Cell Line Endophytes/*chemistry Gas Chromatography-Mass Spectrometry Humans Marchantia/*chemistry Metabolomics/methods Molecular Structure Phytochemicals/*chemistry/*pharmacology Plant Ext;"
Notes:		"MedlineStelmasiewicz, Mateusz Swiatek, Lukasz Ludwiczuk, Agnieszka eng Switzerland 2022/01/12 Molecules. 2021 Dec 28; 27(1):153. doi: 10.3390/molecules27010153"