| Title: | "A Phosphine-mediated Synthesis of 2,3,4,5-tetra-substituted N-hydroxypyrroles from alpha-oximino Ketones and Dialkyl Acetylenedicarboxylates Under Ionic Liquid Green-media" |
| Author(s): | Shahvelayati AS; Ghazvini M; Yadollahzadeh K; Delbari AS; |
| Address: | "Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran. Department of Chemistry, Payame Noor University, P.O. Box, 19395-4697, Tehran, Iran. Department of Chemistry, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran. Department of Chemistry, College of Science, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran" |
| Journal Title: | Comb Chem High Throughput Screen |
| DOI: | 10.2174/1386207321666180124094536 |
| ISSN/ISBN: | 1875-5402 (Electronic) 1386-2073 (Linking) |
| Abstract: | "BACKGROUND: The development of multicomponent reactions (MCRs) in the presence of task-specific ionic liquids (ILs), used not only as environmentally benign reaction media, but also as catalysts, is a new approach that meet with the requirements of sustainable chemistry. In recent years, the use of ionic liquids as a green media for organic synthesis has become a chief study area. This is due to their unique properties such as non-volatility, non-flammability, chemical and thermal stability, immiscibility with both organic compounds and water and recyclability. Ionic liquids are used as environmentally friendly solvents instead of hazardous organic solvents. OBJECTIVE: We report the condensation reaction between alpha-oximinoketone and dialkyl acetylene dicarboxylate in the presence of triphenylphosphine to afford substituted pyrroles under ionic liquid conditions in good yields. RESULT: Densely functionalized pyrroles was easily prepared from reaction of alpha-oximinoketones, dialkyl acetylene dicarboxylate in the presence of triphenylphosphine in a quantitative yield under ionic liquid conditions at room temperature. CONCLUSION: In conclusion, ionic liquids are indicated as a useful and novel reaction medium for the selective synthesis of functionalized pyrroles. This reaction medium can replace the use of hazardous organic solvents. Easy work-up, synthesis of polyfunctional compounds, decreased reaction time, having easily available-recyclable ionic liquids, and good to high yields are advantages of present method" |
| Keywords: | "Alkynes/*chemistry Fatty Acids, Unsaturated/*chemistry Ionic Liquids/*chemistry Ketones/*chemistry Molecular Structure Phosphines/*chemistry Pyrroles/*chemical synthesis/chemistry Dialkyl acetylenedicarboxylate N-hydroxypyrroles green media ionic liquid p;" |
| Notes: | "MedlineShahvelayati, Ashraf S Ghazvini, Maryam Yadollahzadeh, Khadijeh Delbari, Akram S eng United Arab Emirates 2018/01/26 Comb Chem High Throughput Screen. 2018; 21(1):14-18. doi: 10.2174/1386207321666180124094536" |
