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Science

Title:		Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis
Author(s):		Paulsen IT; Banerjei L; Myers GS; Nelson KE; Seshadri R; Read TD; Fouts DE; Eisen JA; Gill SR; Heidelberg JF; Tettelin H; Dodson RJ; Umayam L; Brinkac L; Beanan M; Daugherty S; DeBoy RT; Durkin S; Kolonay J; Madupu R; Nelson W; Vamathevan J; Tran B; Upton J; Hansen T; Shetty J; Khouri H; Utterback T; Radune D; Ketchum KA; Dougherty BA; Fraser CM;
Address:		"Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. ipaulsen@tigr.org"
Journal Title:		Science
Year:		2003
Volume:		299
Issue:		5615
Page Number:		2071 - 2074
DOI:		10.1126/science.1080613
ISSN/ISBN:		1095-9203 (Electronic) 0036-8075 (Linking)
Abstract:		"The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci"
Keywords:		"Adhesins, Bacterial/genetics Bacterial Adhesion Bacterial Proteins/genetics *Biological Evolution Carrier Proteins/genetics/metabolism Chromosomes, Bacterial/genetics Conjugation, Genetic Conserved Sequence DNA Transposable Elements Digestive System/micro;"
Notes:		"MedlinePaulsen, I T Banerjei, L Myers, G S A Nelson, K E Seshadri, R Read, T D Fouts, D E Eisen, J A Gill, S R Heidelberg, J F Tettelin, H Dodson, R J Umayam, L Brinkac, L Beanan, M Daugherty, S DeBoy, R T Durkin, S Kolonay, J Madupu, R Nelson, W Vamathevan, J Tran, B Upton, J Hansen, T Shetty, J Khouri, H Utterback, T Radune, D Ketchum, K A Dougherty, B A Fraser, C M eng AI40963-02/AI/NIAID NIH HHS/ Research Support, U.S. Gov't, P.H.S. 2003/03/29 Science. 2003 Mar 28; 299(5615):2071-4. doi: 10.1126/science.1080613"