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Shi Yan Sheng Wu Xue Bao

Title:		[The role of Cln3 in filamentous growth and invasive growth of Saccharomyces cerevisiae]
Author(s):		Ni J; Liu XY; Chen JY;
Address:		"State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Science, Chinese Academy of Sciences, Shanghai 200031, China"
Journal Title:		Shi Yan Sheng Wu Xue Bao
Year:		2004
Volume:		37
Issue:		2
Page Number:		145 - 150
DOI:
ISSN/ISBN:		0001-5334 (Print) 0001-5334 (Linking)
Abstract:		"Cln3 is one of G1 cyclins in Saccharomyces cerevisiae. In order to study the function of Cln3 in cell cycle and morphogenesis, we constructed a cln3 null mutant and analyzed its phenotype. Our results indicated that the cln3 null mutant was more sensitive to alpha pheromone, and arrested at G1 phase. The hypersensitivity to alpha-pheromone was not suppressed by overexpression of SGV1. The null mutant showed a different phenotype with that of the other two G1 cyclin mutants. The filamentous growth in diploid cells of cln3 mutant was stronger than that in wild type cells, while invasive growth of the haploid cells was partially inhibited. The results suggested that the Cln3 plays a unique function in morphogenesis under a different mechanism with that used by Cln1 and Cln2"
Keywords:		"Cyclin-Dependent Kinases/metabolism/physiology Cyclins/genetics/*physiology G1 Phase Gene Deletion Gene Expression Regulation, Fungal Genes, Fungal Mating Factor Mutation Peptides/pharmacology Phenotype Saccharomyces cerevisiae/genetics/*growth & developm;"
Notes:		"MedlineNi, Jian Liu, Xiao Yan Chen, Jiang Ye chi China 2004/07/21 Shi Yan Sheng Wu Xue Bao. 2004 Apr; 37(2):145-50"