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J R Soc Interface

Title:		Effective delivery of volatile biocides employing mesoporous silicates for treating biofilms
Author(s):		Chan AC; Bravo Cadena M; Townley HE; Fricker MD; Thompson IP;
Address:		"Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK. Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Level 3, Women's Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK. Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, UK. Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, UK ian.thompson@eng.ox.ac.uk"
Journal Title:		J R Soc Interface
Year:		2017
Volume:		14
Issue:		126
Page Number:		-
DOI:		10.1098/rsif.2016.0650
ISSN/ISBN:		1742-5662 (Electronic) 1742-5689 (Print) 1742-5662 (Linking)
Abstract:		"Nanoparticulate delivery of biocides has the potential to decrease levels of exposure to non-target organisms, and miminize long-term exposure that can promote the development of resistance. Silica nanoparticles are an ideal vehicle since they are inert, biocompatible, biodegradable, and thermally and chemically stable. Encapsulation of biocides within nanoparticulates can improve their stability and longevity and maximize the biocidal potential of hydrophobic volatile compounds. Herein, we have shown that the plant secondary metabolites allyl isothiocyanate and cinnamaldehyde demonstrated increased antimicrobial activity against Escherichia coli in planktonic form, when packaged into mesoporous silica nanoparticles. Furthermore, the biocide-loaded nanoparticles showed activity against Pseudomonas aeruginosa biofilms that have inherent resistance to antimicrobial agents. The delivery platform can also be expanded to traditional biocides and other non-conventional antimicrobial agents"
Keywords:		Acrolein/analogs & derivatives/chemistry/pharmacology Allyl Compounds/chemistry/pharmacology *Anti-Infective Agents/chemistry/pharmacology Biofilms/*drug effects/growth & development Drug Delivery Systems/*methods Escherichia coli/*physiology Isocyanates/;
Notes:		"MedlineChan, Andrea C Bravo Cadena, Marimar Townley, Helen E Fricker, Mark D Thompson, Ian P eng England 2017/01/13 J R Soc Interface. 2017 Jan; 14(126):20160650. doi: 10.1098/rsif.2016.0650"