| Title: | Structure-activity relationships in C-terminal fragment analogs of pheromone biosynthesis activating neuropeptide in Helicoverpa zea |
| Author(s): | Kochansky JP; Raina AK; Kempe TG; |
| Address: | "USDA, ARS, Insect Neurobiology and Hormone Laboratory, Beltsville, MD, USA" |
| Journal Title: | Arch Insect Biochem Physiol |
| DOI: | 10.1002/(SICI)1520-6327(199705)35:3<315::AID-ARCH5>3.0.CO;2-S |
| ISSN/ISBN: | 0739-4462 (Print) 0739-4462 (Linking) |
| Abstract: | "A number of analogs of the C-terminal hexapeptide of PBAN were prepared and tested in vivo for pheromonotropic activity in Helicoverpa zea. Peptides prepared with longer-chain omega-aminocarboxylic acids (Tyr-6-aminocaproyl-Leu-NH2 and Tyr-7-aminoheptanoyl-NH2) were active at 25 and 2.5 nmol. Acetyl-Pro-Arg-Leu-NH2 was active at 1,000 pmol and represents a new minimum active fragment in the PBAN system. Addition of a bulky, hydrophobic tail (4-octylphenoxyacetyl) to the C-terminal hexapeptide of PBAN gave an analog that was active at all concentrations tested from 1 to 1,000 pmol when injected, had slight oral activity, but had no activity when applied topically. Glu-Tyr-Phe-Ser-Pro-Arg-Leu-NH2 was active at 1,000 but not at 100 pmol; at the latter dose it synergised the activity of 5 pmol of PBAN" |
| Keywords: | Animals Moths Neuropeptides/chemistry/*metabolism Peptide Fragments/chemistry/metabolism Sex Attractants/chemistry/*metabolism Structure-Activity Relationship; |
| Notes: | "MedlineKochansky, J P Raina, A K Kempe, T G eng 1997/01/01 Arch Insect Biochem Physiol. 1997; 35(3):315-22. doi: 10.1002/(SICI)1520-6327(199705)35:3<315::AID-ARCH5>3.0.CO; 2-S" |
