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Animals (Basel)

Title:		Tannic Acid Induces Intestinal Dysfunction and Intestinal Microbial Dysregulation in Brandt's Voles (Lasiopodomys brandtii)
Author(s):		Gu M; Fan R; Dai X; Gu C; Wang A; Wei W; Yang S;
Address:		"College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, China"
Journal Title:		Animals (Basel)
Year:		2023
Volume:		20230207
Issue:		4
Page Number:		-
DOI:		10.3390/ani13040586
ISSN/ISBN:		2076-2615 (Print) 2076-2615 (Electronic) 2076-2615 (Linking)
Abstract:		"Brandt's vole (Lasiopodomys brandtii) is a small herbivorous mammal that feeds on plants rich in secondary metabolites (PSMs), including tannins. However, plant defense mechanisms against herbivory by Brandt's voles are not clearly established. This study aimed to investigate the effects of dietary tannic acid (TA) on the growth performance, intestinal morphology, digestive enzyme activities, cecal fermentation, intestinal barrier function, and gut microbiota in Brandt's voles. The results showed that TA significantly hindered body weight gain, reduced daily food intake, changed the intestinal morphology, reduced digestive enzyme activity, and increased the serum zonulin levels (p < 0.05). The number of intestinal goblet and mast cells and the levels of serum cytokines and immunoglobulins (IgA, IgG, TNF-alpha, IL-6, and duodenal SlgA) were all reduced by TA (p < 0.05). Moreover, TA altered beta-diversity in the colonic microbial community (p < 0.05). In conclusion, the results indicate that TA could damage the intestinal function of Brandt's voles by altering their intestinal morphology, decreasing digestive ability and intestinal barrier function, and altering microbiota composition. Our study investigated the effects of natural PSMs on the intestinal function of wildlife and improved our general understanding of plant-herbivore interactions and the ecological role of PSMs"
Keywords:		Animals;Brandt's vole gut microbiota intestinal function tannic acid;
Notes:		"PubMed-not-MEDLINEGu, Minghui Fan, Ruiyang Dai, Xin Gu, Chen Wang, Aiqin Wei, Wanhong Yang, Shengmei eng No. 31971418/National Natural Science Foundation of China/ Switzerland 2023/02/26 Animals (Basel). 2023 Feb 7; 13(4):586. doi: 10.3390/ani13040586"