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Environ Int

Title:		Prenatal VOC exposure and redecoration are related to wheezing in early infancy
Author(s):		Franck U; Weller A; Roder SW; Herberth G; Junge KM; Kohajda T; von Bergen M; Rolle-Kampczyk U; Diez U; Borte M; Lehmann I; Li NAS;
Address:		"Helmholtz Centre for Environmental Research - UFZ, Core Facility 'Studies', Leipzig. Germany. Helmholtz Centre for Environmental Research - UFZ, Core Facility 'Studies', Leipzig. Germany; University of Leipzig, Faculty of Medicine, Leipzig. Germany. Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology; Leipzig. Germany. Helmholtz Centre for Environmental Research - UFZ, Department Metabolomics; Leipzig. Germany. Helmholtz Centre for Environmental Research - UFZ, Department Metabolomics; Leipzig. Germany; Helmholtz Centre for Environmental Research - UFZ, Department of Proteomics; Leipzig. Germany; Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg University, Denmark. Helmholtz Centre for Environmental Research - UFZ, Department Metabolomics; Leipzig. Germany; Helmholtz Centre for Environmental Research - UFZ, Department of Proteomics; Leipzig. Germany. Children's Hospital, Municipal Hospital Klinikum St. Georg, Leipzig, Germany. Helmholtz Centre for Environmental Research - UFZ, Core Facility 'Studies', Leipzig. Germany; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology; Leipzig. Germany. Electronic address: irina.lehmann@ufz.de"
Journal Title:		Environ Int
Year:		2014
Volume:		20140918
Issue:
Page Number:		393 - 401
DOI:		10.1016/j.envint.2014.08.013
ISSN/ISBN:		1873-6750 (Electronic) 0160-4120 (Linking)
Abstract:		"Redecoration of dwellings is a common behavior of expecting parents. Former studies gave evidence that early childhood exposure to volatile organic compounds (VOC) resulting from renovation activities may increase the risk for wheeze in infants. OBJECTIVES: The aim of the present study was to evaluate the impact of prenatal exposure on early wheeze and to identify sensitive time windows. Within the LINA birth cohort study data on renovation activities and respiratory outcomes were assessed via questionnaires during pregnancy and at children's age of one. At both timepoints, also indoor VOC concentrations were measured. The associations were studied by logistic regression analysis. Floor covering during pregnancy contributed to an increased risk for physician treated wheeze (adjusted odds ratio OR=5.20, 95% confidence interval 1.8-15.2) during the first 12 months after birth in particular in children with an atopic predisposition. Thereby, wall-to-wall-carpets, PVC material, and laminate were the flooring materials which showed the strongest adverse associations. Floor covering was associated with enhanced concentrations of VOCs in the apartments. For the VOCs styrene, ethylbenzene, octane, 1-butanol, tridecane, and o-xylene, a significant association was found to the occurrence of wheezing symptoms. In contrast to pregnancy, exposure during the first 12 months after birth showed less detrimental associations. Only the association between wheezing and styrene as well as between wheezing and PVC flooring remained significant for exposure after birth. Redecoration during pregnancy, especially changing floor materials, increases the risk for respiratory diseases in early childhood and should therefore be avoided at least in families with a history of atopic diseases"
Keywords:		Cohort Studies Female Floors and Floorcoverings Humans Infant Interior Design and Furnishings Male *Maternal Exposure Pregnancy Prospective Studies Respiratory Sounds/*etiology Volatile Organic Compounds/*analysis Childhood Prenatal exposure Redecoration;
Notes:		"MedlineFranck, Ulrich Weller, Annegret Roder, Stefan W Herberth, Gunda Junge, Kristin M Kohajda, Tibor von Bergen, Martin Rolle-Kampczyk, Ulrike Diez, Ulrike Borte, Michael Lehmann, Irina eng Research Support, Non-U.S. Gov't Netherlands 2014/09/19 Environ Int. 2014 Dec; 73:393-401. doi: 10.1016/j.envint.2014.08.013. Epub 2014 Sep 18"