| Title: | "The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: an in vitro analysis" |
| Author(s): | De Preter V; Falony G; Windey K; Hamer HM; De Vuyst L; Verbeke K; |
| Address: | "Department of Gastrointestinal Research and Leuven Food Science and Nutrition Centre (LFoRCe), University Hospital Gasthuisberg, K.U. Leuven, Leuven, Belgium" |
| ISSN/ISBN: | 1613-4133 (Electronic) 1613-4125 (Linking) |
| Abstract: | "SCOPE: Health benefits of prebiotic administration have been judged mainly from the increased numbers of bifidobacteria and the enhanced production of short-chain fatty acids in the colon. Only a few studies have focused on the capacity of prebiotics to decrease the proteolytic fermentation, which might contribute to health as well. METHODS AND RESULTS: The influence of the prebiotic oligofructose-enriched inulin (OF-IN) on the pattern of volatile organic compounds was characterized using an in vitro faecal model. Faecal slurries, obtained from healthy subjects, were anaerobically incubated at 37 degrees C with and without different doses of OF-IN (2.5, 5, 10, or 20 mg) and changes in the metabolite pattern and pH were evaluated. A total of 107 different volatile organic compounds were identified and classified according to their chemical classes. The concentration of esters and acids significantly increased with increasing doses of OF-IN. Similar effects were observed for some aldehydes. To the contrary, OF-IN dose-dependently inhibited the formation of S-compounds. Also, the generation of other protein fermentation metabolites such as phenolic compounds was inhibited in the presence of OF-IN. CONCLUSION: Our results confirmed a clear dose-dependent stimulation of saccharolytic fermentation. Importantly, a significant decrease in toxic protein fermentation metabolites such as sulphides attended these effects" |
| Keywords: | "Adolescent Adult Bifidobacterium/isolation & purification Colon/microbiology Fatty Acids, Volatile/analysis Feces/*chemistry/microbiology Female Fermentation Humans Inulin/*metabolism Male Multivariate Analysis Oligosaccharides/*metabolism *Prebiotics Vol;" |
| Notes: | "MedlineDe Preter, Vicky Falony, Gwen Windey, Karen Hamer, Henrike M De Vuyst, Luc Verbeke, Kristin eng Research Support, Non-U.S. Gov't Germany 2010/06/23 Mol Nutr Food Res. 2010 Dec; 54(12):1791-801. doi: 10.1002/mnfr.201000136" |
