| Title: | A competence regulon in Streptococcus pneumoniae revealed by genomic analysis |
| Author(s): | Campbell EA; Choi SY; Masure HR; |
| Address: | "Laboratory of Molecular Infectious Diseases, Rockefeller University, New York, NY 10021, USA" |
| DOI: | 10.1046/j.1365-2958.1998.00737.x |
| ISSN/ISBN: | 0950-382X (Print) 0950-382X (Linking) |
| Abstract: | "Transformation in bacteria is the uptake and incorporation of exogenous DNA into a cell's genome. Several species transform naturally during a regulated state defined as competence. Genetic elements in Streptococcus pneumoniae induced during transformation were identified by combining a genetic screen with genomic analysis. Six loci were discovered that composed a competence-induced regulon. These loci shared a consensus promoter sequence and encoded proteins, some of which were similar to proteins involved in DNA processing during transformation in other bacteria. Each locus was induced during competence and essential for genetic transformation" |
| Keywords: | "Consensus Sequence Genome, Bacterial Models, Genetic Open Reading Frames Operon Pheromones Promoter Regions, Genetic Recombinant Fusion Proteins *Regulon Sequence Analysis, DNA Streptococcus pneumoniae/*genetics Transcription, Genetic *Transformation, Bac;" |
| Notes: | "MedlineCampbell, E A Choi, S Y Masure, H R eng AI 36445/AI/NIAID NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1998/04/16 Mol Microbiol. 1998 Mar; 27(5):929-39. doi: 10.1046/j.1365-2958.1998.00737.x" |
