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Curr Biol

Title:		Sexual dimorphism in the fly brain
Author(s):		Cachero S; Ostrovsky AD; Yu JY; Dickson BJ; Jefferis GS;
Address:		"Division of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, UK"
Journal Title:		Curr Biol
Year:		2010
Volume:		20100909
Issue:		18
Page Number:		1589 - 1601
DOI:		10.1016/j.cub.2010.07.045
ISSN/ISBN:		1879-0445 (Electronic) 0960-9822 (Print) 0960-9822 (Linking)
Abstract:		"BACKGROUND: Sex-specific behavior may originate from differences in brain structure or function. In Drosophila, the action of the male-specific isoform of fruitless in about 2000 neurons appears to be necessary and sufficient for many aspects of male courtship behavior. Initial work found limited evidence for anatomical dimorphism in these fru+ neurons. Subsequently, three discrete anatomical differences in central brain fru+ neurons have been reported, but the global organization of sex differences in wiring is unclear. RESULTS: A global search for structural differences in the Drosophila brain identified large volumetric differences between males and females, mostly in higher brain centers. In parallel, saturating clonal analysis of fru+ neurons using mosaic analysis with a repressible cell marker identified 62 neuroblast lineages that generate fru+ neurons in the brain. Coregistering images from male and female brains identified 19 new dimorphisms in males; these are highly concentrated in male-enlarged higher brain centers. Seven dimorphic lineages also had female-specific arbors. In addition, at least 5 of 51 fru+ lineages in the nerve cord are dimorphic. We use these data to predict >700 potential sites of dimorphic neural connectivity. These are particularly enriched in third-order olfactory neurons of the lateral horn, where we provide strong evidence for dimorphic anatomical connections by labeling partner neurons in different colors in the same brain. CONCLUSION: Our analysis reveals substantial differences in wiring and gross anatomy between male and female fly brains. Reciprocal connection differences in the lateral horn offer a plausible explanation for opposing responses to sex pheromones in male and female flies"
Keywords:		Animals Brain/anatomy & histology/physiology Drosophila Proteins/genetics/metabolism *Drosophila melanogaster/anatomy & histology/physiology Female Genotype Male Nerve Tissue Proteins/genetics/metabolism Neurons/cytology/physiology *Sex Characteristics Se;
Notes:		"MedlineCachero, Sebastian Ostrovsky, Aaron D Yu, Jai Y Dickson, Barry J Jefferis, Gregory S X E eng MC_U105188491/MRC_/Medical Research Council/United Kingdom U105188491(88491)/MRC_/Medical Research Council/United Kingdom Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2010/09/14 Curr Biol. 2010 Sep 28; 20(18):1589-601. doi: 10.1016/j.cub.2010.07.045. Epub 2010 Sep 9"