| Title: | Signaling at zero G: G-protein-independent functions for 7-TM receptors |
| Author(s): | Brzostowski JA; Kimmel AR; |
| Address: | "Molecular Mechanisms of Development, Laboratory of Cellular and Developmental Biology, NIDDK/NIH, Bethesda, MD 20892-2715, USA" |
| DOI: | 10.1016/s0968-0004(01)01804-7 |
| ISSN/ISBN: | 0968-0004 (Print) 0968-0004 (Linking) |
| Abstract: | "Eukaryotic cells, whether free-living, single-celled microbes or components of complex metazoa, can sense environmental cues through specialized seven-transmembrane (7-TM) receptors (also called heptahelical or G-protein-coupled receptors). 7-TM receptors detect 'inputs' such as light, peptide hormones, neurotransmitters, pheromones, odorants, morphogens and chemoattractants, linking extracellular stimuli to intracellular signaling networks via heterotrimeric G proteins. Recently, this obligatory paradigm has been challenged. A growing body of evidence indicates that 7-TM receptors can also transmit extracellular signals through mechanisms that function independently of G-protein coupling. This review discusses pathways and protein interactions for 7-TM receptors signaling 'at zero G' in Dictyostelium and mammalian cells" |
| Keywords: | "Animals Cell Membrane/*metabolism Cells, Cultured Cyclic AMP/metabolism Dictyostelium/metabolism Enzyme Activation Eukaryotic Cells/metabolism GTP-Binding Proteins/*metabolism Membrane Proteins/*metabolism Models, Biological Phosphorylation Protein Struct;" |
| Notes: | "MedlineBrzostowski, J A Kimmel, A R eng Review England 2001/05/10 Trends Biochem Sci. 2001 May; 26(5):291-7. doi: 10.1016/s0968-0004(01)01804-7" |
