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MicroPubl Biol

Title:		The roles of several sensory neurons and the feedback from egg laying in regulating the germline response to a sex pheromone in C. elegans hermaphrodites
Author(s):		Aprison EZ; Ruvinsky I;
Address:		"Department of Molecular Biosciences, Northwestern University"
Journal Title:		MicroPubl Biol
Year:		2022
Volume:		20220202
Issue:
Page Number:		-
DOI:		10.17912/micropub.biology.000523
ISSN/ISBN:		2578-9430 (Electronic) 2578-9430 (Linking)
Abstract:		"Animals broadcast small molecule pheromones that can alter behavior and physiology in conspecifics. Neuronal circuits that regulate these processes remain largely unknown. In C. elegans, male-enriched ascaroside sex pheromone ascr#10, in addition to behavioral effects, expands the population of germline precursor cells in hermaphrodites. Previously, we identified several sensory neurons required for this effect. We also found that feedback from egg laying acts via serotonergic signaling to license the pheromone response in reproducing adults. Here, using newly available reagents, we confirm and extend several of our previous conclusions: a) the ADL neurons are essential for the ascr#10 response, b) phasmid neurons (PHA and PHB) are unlikely to be involved in the ascr#10 response, c) the mod-1 receptor is the main conduit of the serotonergic feedback from egg laying, and d) serotonin remains the only currently known signal of this feedback. Our findings better define the neuronal circuits that mediate the germline response to the major male pheromone"
Keywords:
Notes:		"PubMed-not-MEDLINEAprison, Erin Z Ruvinsky, Ilya eng 2022/02/08 MicroPubl Biol. 2022 Feb 2; 2022:10.17912/micropub.biology.000523. doi: 10.17912/micropub.biology.000523. eCollection 2022"