| Title: | Mouse organ coefficient and abnormal sperm rate analysis with exposure to tap water and source water in Nanjing reach of Yangtze River |
| Author(s): | Zhang R; Zhang L; Jiang D; Zheng K; Cui Y; Li M; Wu B; Cheng S; |
| Address: | "State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Xianlin Campus, Nanjing, 210023, People's Republic of China" |
| DOI: | 10.1007/s10646-014-1228-4 |
| ISSN/ISBN: | 1573-3017 (Electronic) 0963-9292 (Linking) |
| Abstract: | "Organ coefficients (including kidney, testis, liver and spleen coefficient) and abnormal sperm rate were used in our study to reflect the exposure to the Yangzte River water. The concentrations of total dissolved metals and semi-volatile organic compounds in tap and source water were measured by ICP-OES and GC-MS, respectively. After mice were fed with purified water (CK), Nanjing tap water (NJT) and Nanjing source water (NJS) for 90 day, the individual and organs (including kidney, testis, liver and spleen) of each mouse were weighted. And abnormal sperm types (such as hook less, banana-like form, amorphous, folded and two tails) were determined by microscope. The results showed that significant differences of liver coefficient between experimental group (NJT, NJS) and control group (CK) were observed; furthermore liver coefficient is positive correlation with the concentrations of total dissolved metals. However, no significant differences of abnormal sperm rates between experimental group (NJT, NJS) and control group (CK) were noted. So liver coefficient might be more sensitive than other organ coefficients to reflect the exposure to tap water and source water, while abnormal sperm rate could not be used to reveal the exposure to them" |
| Keywords: | "Animals China Male Metals/*analysis/toxicity Mice, Inbred ICR Rivers Spermatozoa/*drug effects Volatile Organic Compounds/*analysis/toxicity Water Pollution/*adverse effects Water Supply;" |
| Notes: | "MedlineZhang, Rongfei Zhang, Liujun Jiang, Dongsheng Zheng, Kai Cui, Yibin Li, Mei Wu, Bing Cheng, Shupei eng Research Support, Non-U.S. Gov't 2014/03/26 Ecotoxicology. 2014 May; 23(4):641-6. doi: 10.1007/s10646-014-1228-4. Epub 2014 Mar 25" |
