| Title: | Different structure-function relationships for alpha-factor-induced morphogenesis and agglutination in Saccharomyces cerevisiae |
| Author(s): | Baffi RA; Shenbagamurthi P; Terrance K; Becker JM; Naider F; Lipke PN; |
| DOI: | 10.1128/jb.158.3.1152-1156.1984 |
| ISSN/ISBN: | 0021-9193 (Print) 1098-5530 (Electronic) 0021-9193 (Linking) |
| Abstract: | "Eight synthetic analogs of the mating pheromone alpha-factor-induced morphogenesis and increased agglutinability in a cells. Most analogs induced increased agglutinability at lower concentrations than those at which they induced morphogenesis, but the ratio of the potencies for the two effects varied 140-fold among different analogs. Morphological response to pheromone required exposure for at least 90 min, but increased agglutinability followed exposures of 20 s. Two synthetic analogs induced neither response. In competition experiments, both of these analogs prevented induction of increased agglutinability and morphogenesis by active alpha factor. The inactive peptides blocked increased agglutinability at lower concentrations than those at which they blocked morphogenesis. alpha factors exhibited different structure-function relationships for morphogenesis as compared with agglutinability. Thus, response of Saccharomyces cerevisiae to alpha factor is complex and may be mediated by more than one receptor" |
| Keywords: | Agglutination Kinetics Mating Factor Morphogenesis Peptides/*physiology Saccharomyces cerevisiae/genetics/*physiology Structure-Activity Relationship; |
| Notes: | "MedlineBaffi, R A Shenbagamurthi, P Terrance, K Becker, J M Naider, F Lipke, P N eng GM-22086/GM/NIGMS NIH HHS/ GM-22087/GM/NIGMS NIH HHS/ Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 1984/06/01 J Bacteriol. 1984 Jun; 158(3):1152-6. doi: 10.1128/jb.158.3.1152-1156.1984" |
