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Sci Rep

Title:		Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila
Author(s):		Younus F; Fraser NJ; Coppin CW; Liu JW; Correy GJ; Chertemps T; Pandey G; Maibeche M; Jackson CJ; Oakeshott JG;
Address:		"CSIRO Land and Water, Black Mountain, Canberra, ACT, 2601, Australia. Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia. Universite Pierre et Marie Curie, Institut d'Ecologie et des Sciences de l'Environnement de Paris, 75252, Paris, France"
Journal Title:		Sci Rep
Year:		2017
Volume:		20170410
Issue:
Page Number:		46188 -
DOI:		10.1038/srep46188
ISSN/ISBN:		2045-2322 (Electronic) 2045-2322 (Linking)
Abstract:		"Previous electrophysiological and behavioural studies implicate esterase 6 in the processing of the pheromone cis-vaccenyl acetate and various food odorants that affect aggregation and reproductive behaviours. Here we show esterase 6 has relatively high activity against many of the short-mid chain food esters, but negligible activity against cis-vaccenyl acetate. The crystal structure of esterase 6 confirms its substrate-binding site can accommodate many short-mid chain food esters but not cis-vaccenyl acetate. Immunohistochemical assays show esterase 6 is expressed in non-neuronal cells in the third antennal segment that could be accessory or epidermal cells surrounding numerous olfactory sensilla, including basiconics involved in food odorant detection. Esterase 6 is also produced in trichoid sensilla, but not in the same cell types as the cis-vaccenyl acetate binding protein LUSH. Our data support a model in which esterase 6 acts as a direct odorant degrading enzyme for many bioactive food esters, but not cis-vaccenyl acetate"
Keywords:		"Animals Arthropod Antennae/enzymology Behavior, Animal/*physiology Carboxylesterase/chemistry/*metabolism Catalytic Domain Drosophila Proteins/chemistry/*metabolism Drosophila melanogaster/*enzymology/*physiology Kinetics Models, Molecular *Odorants Recep;"
Notes:		"MedlineYounus, Faisal Fraser, Nicholas J Coppin, Chris W Liu, Jian-Wei Correy, Galen J Chertemps, Thomas Pandey, Gunjan Maibeche, Martine Jackson, Colin J Oakeshott, John G eng Research Support, Non-U.S. Gov't England 2017/04/11 Sci Rep. 2017 Apr 10; 7:46188. doi: 10.1038/srep46188"