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Yeast

Title:		Chemical synthesis of the M-factor mating pheromone from Schizosaccharomyces pombe
Author(s):		Wang SH; Xue CB; Nielsen O; Davey J; Naider F;
Address:		"Department of Chemistry, College of Staten Island, City University of New York 10314"
Journal Title:		Yeast
Year:		1994
Volume:		10
Issue:		5
Page Number:		595 - 601
DOI:		10.1002/yea.320100504
ISSN/ISBN:		0749-503X (Print) 0749-503X (Linking)
Abstract:		"Conjugation in the fission yeast Schizosaccharomyces pombe is controlled by the reciprocal action of mating pheromones. We recently showed that M-factor, the pheromone released by cells of the cellular mating type Minus, is a nonapeptide in which the C-terminal cysteine residue is carboxyl-methylated and S-alkylated, probably with a farnesyl residue (Davey, 1992): Tyr-Thr-Pro-Lys-Val-Pro-Tyr-Met-Cys(S-farnesyl)- OCH3. Here we describe the chemical synthesis of this modified peptide and show that it exhibits all of the properties of the native pheromone. These results confirm the structure of the M-factor while the production of relatively large amounts of pure pheromone will be invaluable for studying the mating response in this yeast"
Keywords:		Amino Acid Sequence DNA-Binding Proteins Intercellular Signaling Peptides and Proteins Molecular Sequence Data Peptides/*chemical synthesis Pheromones/*chemical synthesis Schizosaccharomyces/*chemistry/growth & development *Schizosaccharomyces pombe Prote;
Notes:		"MedlineWang, S H Xue, C B Nielsen, O Davey, J Naider, F eng GM-46520/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 1994/05/01 Yeast. 1994 May; 10(5):595-601. doi: 10.1002/yea.320100504"