| Title: | Mechanisms of Environmental Contributions to Fatty Liver Disease |
| Author(s): | Wahlang B; Jin J; Beier JI; Hardesty JE; Daly EF; Schnegelberger RD; Falkner KC; Prough RA; Kirpich IA; Cave MC; |
| Address: | "Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY, 40202, USA. University of Louisville Superfund Research Center, University of Louisville, Louisville, KY, 40202, USA. Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, 40202, USA. Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, 40202, USA. Hepatobiology & Toxicology COBRE Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA. University of Louisville Alcohol Research Center, University of Louisville, Louisville, KY, 40202, USA. Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Louisville, KY, 40202, USA. matt.cave@louisville.edu. University of Louisville Superfund Research Center, University of Louisville, Louisville, KY, 40202, USA. matt.cave@louisville.edu. Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY, 40202, USA. matt.cave@louisville.edu. Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY, 40202, USA. matt.cave@louisville.edu. Hepatobiology & Toxicology COBRE Center, University of Louisville School of Medicine, Louisville, KY, 40202, USA. matt.cave@louisville.edu. University of Louisville Alcohol Research Center, University of Louisville, Louisville, KY, 40202, USA. matt.cave@louisville.edu. The Robley Rex Veterans Affairs Medical Center, Louisville, KY, 40206, USA. matt.cave@louisville.edu. The Jewish Hospital Liver Transplant Program, Louisville, KY, 40202, USA. matt.cave@louisville.edu. Kosair Charities Clinical & Translational Research Building, 505 South Hancock Street, Louisville, KY, 40202, USA. matt.cave@louisville.edu" |
| DOI: | 10.1007/s40572-019-00232-w |
| ISSN/ISBN: | 2196-5412 (Electronic) 2196-5412 (Linking) |
| Abstract: | "PURPOSE: Fatty liver disease (FLD) affects over 25% of the global population and may lead to liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and environmental chemical exposures is termed 'toxicant-associated steatohepatitis' (TASH). The current review addresses the scientific progress made in the mechanistic understanding of TASH since its initial description in 2010. RECENT FINDINGS: Recently discovered modes of actions for volatile organic compounds and persistent organic pollutants include the following: (i) the endocrine-, metabolism-, and signaling-disrupting chemical hypotheses; (ii) chemical-nutrient interactions and the 'two-hit' hypothesis. These key hypotheses were then reviewed in the context of the steatosis adverse outcome pathway (AOP) proposed by the US Environmental Protection Agency. The conceptual understanding of the contribution of environmental exposures to FLD has progressed significantly. However, because this is a new research area, more studies including mechanistic human data are required to address current knowledge gaps" |
| Keywords: | Carcinogens/*toxicity Endocrine Disruptors/*adverse effects Environmental Exposure/*adverse effects Environmental Pollutants/*toxicity Humans Non-alcoholic Fatty Liver Disease/*chemically induced/epidemiology Pesticides/toxicity Risk Factors Endocrine dis; |
| Notes: | "MedlineWahlang, Banrida Jin, Jian Beier, Juliane I Hardesty, Josiah E Daly, Erica F Schnegelberger, Regina D Falkner, K Cameron Prough, Russell A Kirpich, Irina A Cave, Matthew C eng P20 GM113226/GM/NIGMS NIH HHS/ L30 AA027913/AA/NIAAA NIH HHS/ K01 DK096042/DK/NIDDK NIH HHS/ P50 AA024337/AA/NIAAA NIH HHS/ T32 ES011564/ES/NIEHS NIH HHS/ F31 ES028982/ES/NIEHS NIH HHS/ T35 ES014559/ES/NIEHS NIH HHS/ R01 AA024102/AA/NIAAA NIH HHS/ R03 DK107912/DK/NIDDK NIH HHS/ R35 ES028373/ES/NIEHS NIH HHS/ P42 ES023716/ES/NIEHS NIH HHS/ Research Support, N.I.H., Extramural Review Switzerland 2019/05/28 Curr Environ Health Rep. 2019 Sep; 6(3):80-94. doi: 10.1007/s40572-019-00232-w" |
