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Proc Natl Acad Sci U S A

Title:		Kinetic properties of a sex pheromone-degrading enzyme: the sensillar esterase of Antheraea polyphemus
Author(s):		Vogt RG; Riddiford LM; Prestwich GD;
Address:
Journal Title:		Proc Natl Acad Sci U S A
Year:		1985
Volume:		82
Issue:		24
Page Number:		8827 - 8831
DOI:		10.1073/pnas.82.24.8827
ISSN/ISBN:		0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking)
Abstract:		"Behavioral and electrophysiological evidence has suggested that sex pheromone is rapidly inactivated within the sensory hairs soon after initiation of the action-potential spike. We report the isolation and characterization of a sex-pheromone-degrading enzyme from the sensory hairs of the silkmoth Antheraea polyphemus. In the presence of this enzyme at physiological concentration, the pheromone [(6E,11Z)-hexadecadienyl acetate] has an estimated half-life of 15 msec. Our findings suggest a molecular model for pheromone reception in which a previously reported pheromone-binding protein acts as a pheromone carrier, and an enzyme acts as a rapid pheromone inactivator, maintaining a low stimulus noise level within the sensory hairs"
Keywords:		"Acetates/metabolism Animal Communication Animals Esterases/antagonists & inhibitors/*metabolism Hemolymph/metabolism Kinetics Lepidoptera/*enzymology Moths/*enzymology Pheromones/*metabolism Receptors, Cell Surface/physiology;"
Notes:		"MedlineVogt, R G Riddiford, L M Prestwich, G D eng GM07108/GM/NIGMS NIH HHS/ GM07270/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 1985/12/01 Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8827-31. doi: 10.1073/pnas.82.24.8827"