| Title: | "Effects of volatile organic compounds and carbon monoxide mixtures on learning and memory, oxidative stress, and monoamine neurotransmitters in the brains of mice" |
| Author(s): | Wang F; Fangfang Z; Guo X; Chen W; Yao W; Liu H; Lyu C; Zhang Y; Fan C; |
| Address: | "1 School of Biological Science, Luoyang Normal University, Luoyang, China. 2 Cold Water Fish Breeding Engineering Technology Research Center of Henan Province, Luoyang, China. 3 School of Energy and Environment Engineering, Zhongyuan University of Technology, Zhengzhou, China. 4 College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China" |
| ISSN/ISBN: | 1477-0393 (Electronic) 0748-2337 (Linking) |
| Abstract: | "In this study, we investigated the effect of inhaled mixtures of volatile organic compounds (VOCs) and carbon monoxide (CO) on neuroethology. Fifty 6-week-old male Kunming mice were exposed in five similar static chambers; zero (control) and four different doses of VOC and CO mixtures (G1-G4) for 10 consecutive days and 2 h/day. The compounds and concentrations were as follows: formaldehyde, benzene, toluene, xylene, and CO as 0.10 + 0.11 + 0.20 + 0.20 + 10.00 mg/m(3), 0.20 + 0.22 + 0.40 + 0.40 + 20.00 mg/m(3), 1.00 + 1.10 + 2.00 + 2.00 + 100.00 mg/m(3), and 5.00 + 5.50 + 10.00 + 10.00 + 500.00 mg/m(3), respectively, which corresponded to 1, 2, 10, and 50 times the indoor air quality standard in China. Morris water maze and grip strength tests were performed during the exposure experiment. One day following the final exposure, oxidative damage levels, monoamine neurotransmitters, monoamine oxidase (MAO), and morphology of mice brain were analyzed. Escape latency, dopamine, norepinephrine (NE), and serotonin decreased significantly, while total antioxidant capacity, glutathione peroxidase, and MAO increased significantly in G3 and G4. In addition, there were morphological changes and degeneration of neurons in the dentate gyrus regions of the hippocampus in G4. Results showed that the inhaled mixtures of VOCs and CO affected learning and memory of mice. The impairment of monoamine neurotransmitter associated with MAO may be one of the mechanisms of learning and memory impairment of the mice induced by the mixtures of VOCs and CO" |
| Keywords: | "Air Pollution, Indoor/adverse effects Analysis of Variance Animals Benzene Brain/*drug effects Carbon Monoxide/*toxicity China Formaldehyde Learning/drug effects Male Memory/drug effects Mice Monoamine Oxidase/drug effects Neurotransmitter Agents/*toxicit;" |
| Notes: | "MedlineWang, Fan Fangfang, Zheng Guo, Xiangmeng Chen, Wanguang Yao, Weiyun Liu, Haifang Lyu, Chengcai Zhang, Yaowen Fan, Chaojie eng Comparative Study England 2018/03/07 Toxicol Ind Health. 2018 Mar; 34(3):178-187. doi: 10.1177/0748233717747504. Epub 2018 Mar 5" |
