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J Sci Food Agric

Title:		"Chemical composition and antibacterial, antifungal, allelopathic and acetylcholinesterase inhibitory activities of cassumunar-ginger"
Author(s):		Verma RS; Joshi N; Padalia RC; Singh VR; Goswami P; Verma SK; Iqbal H; Chanda D; Verma RK; Darokar MP; Chauhan A; Kandwal MK;
Address:		"CSIR-Central Institute of Medicinal and Aromatic Plants, Research Centre Pantnagar, Udham Singh Nagar, Uttarakhand, India. Department of Chemistry, MB Govt PG College Haldwani, Kumaun University Nainital, Uttarakhand, India. CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India. Botanical Survey of India-APRC, Senki View, Itanagar, Arunachal Pradesh, India"
Journal Title:		J Sci Food Agric
Year:		2018
Volume:		20170724
Issue:		1
Page Number:		321 - 327
DOI:		10.1002/jsfa.8474
ISSN/ISBN:		1097-0010 (Electronic) 0022-5142 (Linking)
Abstract:		"BACKGROUND: Zingiber montanum (J.Koenig) Link ex A.Dietr. (Zingiberaceae), commonly known as cassumunar-ginger, is a folk remedy for the treatment of inflammations, sprains, rheumatism and asthma. The aim of the present study was to assess the chemical composition, and antibacterial, antifungal, allelopathic and acetylcholinesterase inhibitory activities of the essential oil of Z. montanum originating from India. RESULTS: The hydrodistilled essential oil of Z. montanum rhizome was analyzed using gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. A total of 49 constituents, forming 98.7-99.9% of the total oil compositions, was identified. The essential oil was characterized by higher amount of monoterpene hydrocarbons (32.6-43.5%), phenylbutanoids (27.5-41.2%) and oxygenated monoterpenes (11.4-34.1%). Major constituents of the oil were sabinene (13.5-38.0%), (E)-1-(3',4'-dimethoxyphenyl)buta-1,3-diene (DMPBD) (20.6-35.3%), terpinen-4-ol (9.0-31.3%), gamma-terpinene (1.1-4.8%) and beta-phellandrene (1.0-4.4%). The oil was evaluated against eight pathogenic bacteria and two fungal strains. It exhibited low to good antibacterial activity (minimum inhibitory concentration: 125-500 microg mL(-1) ) and moderate antifungal activity (250 microg mL(-1) ) against the tested strains. The oil reduced germination (69.8%) and inhibited the root and shoot growth of lettuce significantly (LD(50) : 3.58 microL plate(-1) ). However, it did not demonstrate acetylcholinesterase inhibitory activity up to a concentration of 10 mg mL(-1) . CONCLUSIONS: The essential oil of Z. montanum can be used as a potential source of DMPBD, terpinen-4-ol and sabinene for pharmaceutical products. The results of the present study add significant information to the pharmacological activity of Z. montanum native to India. (c) 2017 Society of Chemical Industry"
Keywords:		Acetylcholinesterase/chemistry Allelopathy Anti-Bacterial Agents/*chemistry/pharmacology Antifungal Agents/*chemistry/pharmacology Bacteria/drug effects Cholinesterase Inhibitors/*chemistry/pharmacology Fungi/drug effects Lettuce/drug effects/growth & dev;
Notes:		"MedlineVerma, Ram S Joshi, Neeta Padalia, Rajendra C Singh, Ved R Goswami, Prakash Verma, Sajendra K Iqbal, Hina Chanda, Debabrata Verma, Rajesh K Darokar, Mahendra P Chauhan, Amit Kandwal, Manish K eng England 2017/06/07 J Sci Food Agric. 2018 Jan; 98(1):321-327. doi: 10.1002/jsfa.8474. Epub 2017 Jul 24"