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Anal Bioanal Chem

Title:		Evaluation of potential breath biomarkers for active smoking: assessment of smoking habits
Author(s):		Alonso M; Castellanos M; Sanchez JM;
Address:		"Department of Chemistry, University of Girona, 17071 Gerona, Spain"
Journal Title:		Anal Bioanal Chem
Year:		2010
Volume:		20100226
Issue:		8
Page Number:		2987 - 2995
DOI:		10.1007/s00216-010-3524-z
ISSN/ISBN:		1618-2650 (Electronic) 1618-2642 (Linking)
Abstract:		"Different compounds have been reported as biomarkers of a smoking habit, but, to date, there is no appropriate biomarker for tobacco-related exposure because the proposed chemicals seem to be nonspecific or they are only appropriate for short-term exposure. Moreover, conventional sampling methodologies require an invasive method because blood or urine samples are required. The use of a microtrap system coupled to gas chromatography-mass spectrometry analysis has been found to be very effective for the noninvasive analysis of volatile organic compounds in breath samples. The levels of benzene, 2,5-dimethylfuran, toluene, o-xylene, and m- p-xylene have been analyzed in breath samples obtained from 204 volunteers (100 smokers, 104 nonsmokers; 147 females, 57 males; ages 16 to 53 years). 2,5-Dimethylfuran was always below the limit of detection (0.005 ppbv) in the nonsmoker population and always detected in smokers independently of the smoking habits. Benzene was only an effective biomarker for medium and heavy smokers, and its level was affected by smoking habits. Regarding the levels of xylenes and toluene, they were only different in heavy smokers and after short-term exposure. The results obtained suggest that 2,5-dimethylfuran is a specific breath biomarker of smoking status independently of the smoking habits (e.g., short- and long-term exposure, light and heavy consumption), and so this compound might be useful as a biomarker of smoking exposure"
Keywords:		Adolescent Adult Biomarkers/analysis Breath Tests/*methods Female Gas Chromatography-Mass Spectrometry Humans Male Middle Aged *Smoking Tobacco Smoke Pollution/*analysis Young Adult;
Notes:		"MedlineAlonso, Monica Castellanos, Mar Sanchez, Juan M eng Research Support, Non-U.S. Gov't Germany 2010/02/27 Anal Bioanal Chem. 2010 Apr; 396(8):2987-95. doi: 10.1007/s00216-010-3524-z. Epub 2010 Feb 26"