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Rapid Commun Mass Spectrom

Title:		Impact of oral cleansing strategies on exhaled volatile organic compound levels
Author(s):		Vadhwana B; Belluomo I; Boshier PR; Pavlou C; Spanel P; Hanna GB;
Address:		"Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, London, UK. J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic"
Journal Title:		Rapid Commun Mass Spectrom
Year:		2020
Volume:		34
Issue:		9
Page Number:		e8706 -
DOI:		10.1002/rcm.8706
ISSN/ISBN:		1097-0231 (Electronic) 0951-4198 (Linking)
Abstract:		"RATIONALE: The analysis of volatile organic compounds (VOCs) within exhaled breath potentially offers a non-invasive method for the detection and surveillance of human disease. Oral contamination of exhaled breath may influence the detection of systemic VOCs relevant to human disease. This study aims to assess the impact of oral cleansing strategies on exhaled VOC levels in order to standardise practice for breath sampling. METHODS: Ten healthy volunteers consumed a nutrient challenge followed by four oral cleansing methods: (a) water, (b) saltwater, (c) toothbrushing, and (d) alcohol-free mouthwash. Direct breath sampling was performed using selected ion flow tube mass spectrometry after each intervention. RESULTS: Proposed reactions suggest that volatile fatty acid and alcohol levels (butanoic, pentanoic acid, ethanol) declined with oral cleansing interventions, predominantly after an initial oral rinse with water. Concentrations of aldehydes and phenols (acetaldehyde, menthone, p-cresol) declined with oral water rinse; however, they increased after toothbrushing and mouthwash use, secondary to flavoured ingredients within these products. No significant reductions were observed with sulphur compounds. CONCLUSIONS: Findings suggest that oral rinsing with water prior to breath sampling may reduce oral contamination of VOC levels, and further interventions for oral decontamination with flavoured products may compromise results. This intervention may serve as a simple and inexpensive method of standardisation within breath research"
Keywords:		Breath Tests/*methods Exhalation Humans Mass Spectrometry/methods Oral Hygiene Specimen Handling/methods Toothbrushing Volatile Organic Compounds/*analysis;
Notes:		"MedlineVadhwana, Bhamini Belluomo, Ilaria Boshier, Piers R Pavlou, Chrystalla Spanel, Patrik Hanna, George B eng England 2019/12/28 Rapid Commun Mass Spectrom. 2020 May 15; 34(9):e8706. doi: 10.1002/rcm.8706"