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Nutr Rev

Title:		Detection of odorants through the main olfactory epithelium and vomeronasal organ of mice
Author(s):		Trinh K; Storm DR;
Address:		"Department of Pharmacology, University of Washington, Seattle 98195-7280, USA"
Journal Title:		Nutr Rev
Year:		2004
Volume:		62
Issue:		11 Pt 2
Page Number:		S189 - S192
DOI:		10.1111/j.1753-4887.2004.tb00098.x
ISSN/ISBN:		0029-6643 (Print) 0029-6643 (Linking)
Abstract:		"Previous research has indicated that volatile odorants are detected through the main olfactory epithelium (MOE), whereas pheromones are detected via the vomeronasal organ (VNO). Gene disruption studies have established that olfactory signaling through the MOE is mediated through receptor stimulation of type 3 adenylyl cyclase (AC3). Mice lacking AC3 cannot detect odorants through the MOE. Recently, it was discovered using olfactory-based behavioral assays that AC3 mutant mice can detect some volatile odorants. An analysis of these mutant mice led to the surprising discovery that some odorants are detected through the VNO"
Keywords:		"Adenylyl Cyclases/physiology Animals Mice *Odorants Olfactory Mucosa/*physiology Receptors, Odorant/physiology Receptors, Pheromone/physiology Second Messenger Systems/physiology Signal Transduction Smell Volatilization Vomeronasal Organ/*physiology;"
Notes:		"MedlineTrinh, Kien Storm, Daniel R eng Review 2005/01/06 Nutr Rev. 2004 Nov; 62(11 Pt 2):S189-92; discussion S224-41. doi: 10.1111/j.1753-4887.2004.tb00098.x"