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J Cell Biol

Title:		Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast
Author(s):		Tang X; Jin Y; Cande WZ;
Address:		"Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA"
Journal Title:		J Cell Biol
Year:		2006
Volume:		20060612
Issue:		6
Page Number:		845 - 851
DOI:		10.1083/jcb.200602152
ISSN/ISBN:		0021-9525 (Print) 1540-8140 (Electronic) 0021-9525 (Linking)
Abstract:		"The telomere bouquet, i.e., telomere clustering on the nuclear envelope (NE) during meiotic prophase, is thought to promote homologous chromosome pairing. Using a visual screen, we identified bqt2/im295, a mutant that disrupts telomere clustering in fission yeast. Bqt2p is required for linking telomeres to the meiotic spindle pole body (SPB) but not for attachment of telomeres or the SPB to the NE. Bqt2p is expressed upon pheromone sensing and colocalizes thereafter to Sad1p, an SPB protein. This localization only depends on Bqt1p, not on other identified proteins required for telomere clustering. Upon pheromone sensing, generation of Sad1p foci next to telomeres depends on Bqt2p. However, depletion of Bqt2p from the SPB is dispensable for dissolving the telomere bouquet at the end of meiotic prophase. Therefore, telomere bouquet formation requires Bqt2p as a linking component and is finely regulated during meiotic progression"
Keywords:		Heterochromatin/metabolism Mutation Pheromones/*metabolism Prophase Schizosaccharomyces/*metabolism Schizosaccharomyces pombe Proteins/genetics/metabolism/*physiology Shelterin Complex Spindle Apparatus/metabolism Telomere/*metabolism Telomere-Binding Pro;
Notes:		"MedlineTang, Xie Jin, Ye Cande, W Zacheus eng R01 GM067992/GM/NIGMS NIH HHS/ R01-GM067992/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural 2006/06/14 J Cell Biol. 2006 Jun 19; 173(6):845-51. doi: 10.1083/jcb.200602152. Epub 2006 Jun 12"