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J Ethnopharmacol

Title:		"Centipeda minima: An update on its phytochemistry, pharmacology and safety"
Author(s):		Tan J; Qiao Z; Meng M; Zhang F; Kwan HY; Zhong K; Yang C; Wang Y; Zhang M; Liu Z; Su T;
Address:		"International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address: tanjincheng0571@163.com. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address: qiaozhiping1020@163.com. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address: mingjingmeng2018@163.com. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address: serzhang@163.com. Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. Electronic address: hykwan@hkbu.edu.hk. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address: zky371622413@163.com. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address: 15235479186@163.com. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address: whclxqw@163.com. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address: zmnl23@163.com. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address: liuzq@gzucm.edu.cn. International Institute for Translational Chinese Medicine, School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China; Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau. Electronic address: sutao@gzucm.edu.cn"
Journal Title:		J Ethnopharmacol
Year:		2022
Volume:		20220126
Issue:
Page Number:		115027 -
DOI:		10.1016/j.jep.2022.115027
ISSN/ISBN:		1872-7573 (Electronic) 0378-8741 (Linking)
Abstract:		"ETHNOPHARMACOLOGICAL RELEVANCE: Centipeda minima (CM), the dried whole plant of Centipeda minima (L.) A. Braun and Aschers, has been used as a traditional Chinese medicinal herb for thousands of years for the treatments of rhinitis, sinusitis, cough and asthmatic diseases. This review aimed to evaluate the therapeutic potential of CM by summarizing its phytochemistry, pharmacology, clinical application and safety. METHODS: This review summarizes the published studies on CM in the Chinese Pharmacopoeia and literature databases including PubMed, Web of Science, Baidu Scholar, Wiley and China Knowledge Resource Integrated Database (CNKI), as well as the research articles on the phytochemistry, pharmacology, clinical application and safety of CM. RESULTS: A total of 191 compounds have been isolated and identified from CM, including terpenes, flavonoids, sterols, phenols, organic acids and volatile oils. In addition, the pharmacological effects of CM, such as anti-cancer, anti-inflammatory and anti-bacterial activities, have also been evaluated by both in vitro and in vivo studies. The signaling pathways and mechanisms of action underlying the anti-cancer effects of CM have been revealed. Clinical applications of CM mainly include rhinitis and sinusitis, gynecological inflammation, cough, as well as asthma. CONCLUSION: CM is a medicinal herb that possesses many therapeutic effects. Cutting-edge technology and system biology could provide us a more comprehensive understanding of the therapeutic effects, constituting components and toxicity of CM, which are the prerequisites for its translation into therapeutics for various disease treatments"
Keywords:		"*Asteraceae Cough/drug therapy Ethnopharmacology Humans Medicine, Chinese Traditional Phytochemicals/adverse effects Plant Extracts/pharmacology *Plants, Medicinal *Rhinitis/drug therapy Centipeda minima Clinical application Folk herb Pharmacology Phytoch;"
Notes:		"MedlineTan, Jincheng Qiao, Zhiping Meng, Mingjing Zhang, Fan Kwan, Hiu Yee Zhong, Keying Yang, Chunfang Wang, Yechun Zhang, Mi Liu, Zhongqiu Su, Tao eng Review Ireland 2022/01/30 J Ethnopharmacol. 2022 Jun 28; 292:115027. doi: 10.1016/j.jep.2022.115027. Epub 2022 Jan 26"