| Title: | Neurospora crassa a mating-type region |
| Address: | "Department of Biological Sciences, Stanford University, CA 94305-5020" |
| ISSN/ISBN: | 0027-8424 (Print) 1091-6490 (Electronic) 0027-8424 (Linking) |
| Abstract: | "The a mating-type region of Neurospora crassa controls several major events in both the sexual and asexual phases of the fungal life cycle. This 3235-base-pair DNA segment is not homologous to the comparable genetic region of the A mating type. The unique a and A regions are bordered by nearly identical DNA sequences. The a genetic region contains at least two functional segments. One segment encodes a perithecium maturation function that is dependent on the second segment for phenotypic expression. This second a segment encodes a spliced mRNA that specifies the mt a-1 polypeptide. This polypeptide appears to be responsible for vegetative incompatibility, mating identity, and perithecium induction. The a-1 transcript is produced vegetatively and under conditions that induce sexual differentiation. The amino-terminal half of the mt a-1 polypeptide is homologous to the shorter Schizosaccharomyces pombe mat-Mc polypeptide. This homology and the properties of mt a-1 mutants suggest that the a-1 polypeptide segment that is homologous to the mat-Mc polypeptide may be primarily responsible for mating functions, while the distal segment is required for vegetative incompatibility" |
| Keywords: | "Amino Acid Sequence Base Sequence Cloning, Molecular DNA, Fungal/genetics Escherichia coli/genetics Genes, Fungal Genes, Mating Type, Fungal Molecular Sequence Data Neurospora/*genetics Neurospora crassa/*genetics Pheromones/genetics Polymerase Chain Reac;" |
| Notes: | "MedlineStaben, C Yanofsky, C eng Comparative Study Research Support, Non-U.S. Gov't 1990/07/01 Proc Natl Acad Sci U S A. 1990 Jul; 87(13):4917-21. doi: 10.1073/pnas.87.13.4917" |
