| Title: | Constitutive mutants in the yeast pheromone response: ordered function of the gene products |
| Author(s): | Blinder D; Bouvier S; Jenness DD; |
| Address: | "Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655" |
| DOI: | 10.1016/0092-8674(89)90250-x |
| ISSN/ISBN: | 0092-8674 (Print) 0092-8674 (Linking) |
| Abstract: | "The alpha factor pheromone inhibits the division of yeast a cells. A general method was developed for isolating mutants that exhibit constitutive activation of the pheromone response pathway. A dominant allele of the STE4 locus was recovered in addition to recessive mutations in the SCG1 gene. SCG1 and STE4 are known to encode G alpha and G beta homologs, respectively. Analysis of double mutants suggests that the STE4 gene product functions after the SCG1 product but before the STE5 product" |
| Keywords: | "Crosses, Genetic *Genes Genes, Dominant *Genes, Fungal Genes, Recessive Genotype Mating Factor *Mutation Peptides/*genetics/physiology Phenotype Pheromones/*genetics Saccharomyces cerevisiae/*genetics/physiology;" |
| Notes: | "MedlineBlinder, D Bouvier, S Jenness, D D eng GM34719/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1989/02/10 Cell. 1989 Feb 10; 56(3):479-86. doi: 10.1016/0092-8674(89)90250-x" |
