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Food Chem Toxicol

Title:		Embryonic exposure to octylphenol induces changes in testosterone levels and disrupts reproductive efficiency in rats at their adulthood
Author(s):		Sainath SB; Meena R; Kumar CH; Kalapana P; Swetha KN; Devi NS; Reddy PS;
Address:		"Department of Biotechnology, Sri Venkateswara University, Tirupati 517 502, India"
Journal Title:		Food Chem Toxicol
Year:		2011
Volume:		20110108
Issue:		4
Page Number:		983 - 990
DOI:		10.1016/j.fct.2011.01.004
ISSN/ISBN:		1873-6351 (Electronic) 0278-6915 (Linking)
Abstract:		"The purpose of the present study was to investigate the effects of prenatal exposure to octylphenol (OP) at the dose of 50mg/kg body weight on days 1, 7 and 14 of pregnancy on reproductive health of male rats at adulthood. F1 male rats from control and OP exposed animals were weaned and maintained up to postnatal day (PND) 100. The indices of testis, epididymis and seminal vesicles were significantly decreased in male rats exposed to OP during embryonic development when compared with controls. Significant reduction in the epididymal sperm count, viable sperms and motile sperms and number of tail coiled sperms (HOS-test) were observed in experimental rats when compared to control rats. The levels of serum testosterone and also activity levels of testicular hydroxysteroid dehydrogenases were significantly decreased with a significant increase in the serum follicle stimulating and leutinizing hormones in experimental rats. Furthermore, embryonic exposure to OP caused significant down regulation of StAR, 3ss hydroxysteroid dehydrogenase and 17ss hydroxysteroid dehydrogenase mRNAs in testis of adult rats as compared to control rats. The results of fertility studies revealed that there was an increase in the mating index in experimental rats with an increase in the pre- and post-implantation losses in rats cohabited with treated animals indicating poor male reproductive performance"
Keywords:		Animals Base Sequence DNA Primers Female Male Maternal-Fetal Exchange Phenols/*toxicity Pregnancy *Prenatal Exposure Delayed Effects Radioimmunoassay Rats Reproduction/*drug effects Reverse Transcriptase Polymerase Chain Reaction Spermatozoa/drug effects;
Notes:		"MedlineSainath, S B Meena, R Kumar, C H Venkata Suneel Kalapana, P Swetha, K N Devi, N Syamala Reddy, P Sreenivasula eng Research Support, Non-U.S. Gov't England 2011/01/12 Food Chem Toxicol. 2011 Apr; 49(4):983-90. doi: 10.1016/j.fct.2011.01.004. Epub 2011 Jan 8"