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Arch Microbiol

Title:		"Inducible expression and cellular location of AgrB, a protein involved in the maturation of the staphylococcal quorum-sensing pheromone"
Author(s):		Saenz HL; Augsburger V; Vuong C; Jack RW; Gotz F; Otto M;
Address:		"Mikrobielle Genetik, Universitat Tubingen, Germany"
Journal Title:		Arch Microbiol
Year:		2000
Volume:		174
Issue:		6
Page Number:		452 - 455
DOI:		10.1007/s002030000223
ISSN/ISBN:		0302-8933 (Print) 0302-8933 (Linking)
Abstract:		"AgrB has been suggested to be responsible for the posttranslational modification in staphylococci that leads to the production of the thiolactone-containing agr peptide pheromone. We demonstrate that AgrB is located in the cytoplasmic membrane. Vectors were constructed for the xylose-inducible overexpression of agrB, and of agrB and agrD together. A Staphylococcus epidermidis strain deleted for agr and containing these vectors was assayed for AgrB protein and pheromone production. The lack of adequate pheromone production suggests the involvement of additional factors in the production of the agr pheromone"
Keywords:		"Bacterial Proteins/*genetics/*metabolism Cell Membrane/metabolism Culture Media Gene Expression Regulation, Bacterial Peptides, Cyclic/*metabolism Pheromones/*metabolism Plasmids Staphylococcus epidermidis/*genetics/metabolism *Trans-Activators Transcript;"
Notes:		"MedlineSaenz, H L Augsburger, V Vuong, C Jack, R W Gotz, F Otto, M eng Germany 2001/02/24 Arch Microbiol. 2000 Dec; 174(6):452-5. doi: 10.1007/s002030000223"