« Previous AbstractAerial Warfare: A Volatile Dialogue between the Plant Pathogen Verticillium longisporum and Its Antagonist Paenibacillus polymyxa    Next AbstractAntennal-specific pheromone-degrading aldehyde oxidases from the moths Antheraea polyphemus and Bombyx mori »

Zh Mikrobiol Epidemiol Immunobiol

Title:		[Antimicrobial peptides of lactobacilli]
Author(s):		Rybal'chenko OV; Orlova OG; Bondarenko VM;
Address:
Journal Title:		Zh Mikrobiol Epidemiol Immunobiol
Year:		2013
Volume:
Issue:		4
Page Number:		89 - 100
DOI:
ISSN/ISBN:		0372-9311 (Print) 0372-9311 (Linking)
Abstract:		"Data on antimicrobial peptides (AMP) of lactobacilli, mechanism of their damagin effect, chemical nature and genetic control are presented. Regardless of the source of isolation AMP of lactobacilli except reuterin are peptides with low molecular weight (4 - 6 kDa), differ from each other by chemical structure, sensitivity to temperature, effect of various enzymes, active at neutral or more frequently low pH. Especially important are mechanisms ensuring fine regulation of phenotypic expression of bacteriocin synthesis and formation of immunity against their effect. Activity and most importantly the level of their production depend on the conditions in which these bacteria are present and are controlled by a three-component regulation system. This system includes signal peptide (pheromone), sensory histidine kinase, regulator protein activating transcription. Resistance of the producer to the effect of its own bacteriocin is ensured by the so called immunity protein. AMP of lactobacilli are able to influence septoformation, peptidoglycan and protein synthesis, affect cytoplasmic membranes causing their destabilization. Stages of this damaging effect are described: interaction of effector peptides with the membrane of the sensitive cell, positioning of the peptide in the region of connection with protein receptor, submerging into the core of the spiral structure membranes with the formation of a pore and exhaustion of ATP pool leading to cell death. Protection from AMP is determined by specific proteins blocking pore formation in the membrane by direct binding of damaging molecules or their receptors. Perspectives of further studies of the role of antimicrobial peptides of lactobacilli are discussed"
Keywords:		"Anti-Infective Agents/*chemistry/metabolism/pharmacology Bacteria/drug effects/pathogenicity Bacteriocins/*chemistry/genetics/metabolism Gene Expression Regulation, Bacterial Humans Lactobacillus/*chemistry/genetics Peptide Biosynthesis Peptides/*chemistr;"
Notes:		"MedlineRybal'chenko, O V Orlova, O G Bondarenko, V M rus English Abstract Review Russia (Federation) 2013/12/18 Zh Mikrobiol Epidemiol Immunobiol. 2013 Jul-Aug; (4):89-100"