| Title: | "Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function" |
| Author(s): | Rupasinghe DB; Knapp O; Blomster LV; Schmid AB; Adams DJ; King GF; Ruitenberg MJ; |
| Address: | "Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia" |
| ISSN/ISBN: | 1933-6969 (Electronic) 1933-6950 (Linking) |
| Abstract: | "Loss-of-function mutations in the pore-forming alpha subunit of the voltage-gated sodium channel 1.7 (Nav 1.7) cause congenital indifference to pain and anosmia. We used immunohistochemical techniques to study Nav 1.7 localization in the rat olfactory system in order to better understand its role in olfaction. We confirm that Nav 1.7 is expressed on olfactory sensory axons and report its presence on vomeronasal axons, indicating an important role for Nav 1.7 in transmission of pheromonal cues. Following neuroepithelial injury, Nav 1.7 was transiently expressed by cells of monocytic lineage. These findings support an emerging role for Nav 1.7 in immune function. This sodium channel may provide an important pharmacological target for treatment of inflammatory injury and inflammatory pain syndromes" |
| Keywords: | "Animals Axons/metabolism CHO Cells Cricetinae Cricetulus Humans Immunohistochemistry Male Monocytes/immunology/metabolism NAV1.7 Voltage-Gated Sodium Channel Olfactory Bulb/cytology Olfactory Mucosa/drug effects/innervation/*metabolism Rats Rats, Sprague-;" |
| Notes: | "MedlineRupasinghe, Darshani B Knapp, Oliver Blomster, Linda V Schmid, Annina B Adams, David J King, Glenn F Ruitenberg, Marc J eng Research Support, Non-U.S. Gov't 2012/05/25 Channels (Austin). 2012 Mar-Apr; 6(2):103-10. doi: 10.4161/chan.19484. Epub 2012 Mar 1" |
