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Clin Lung Cancer

Title:		Cancer treatments: can we find treasures at the bottom of the sea?
Author(s):		Provencio M; Sanchez A; Gasent J; Gomez P; Rosell R;
Address:		"Medical Oncology Service, Hospital Universitario Clinica Puerta de Hierro, Madrid, Spain. mprovenciop@yahoo.es"
Journal Title:		Clin Lung Cancer
Year:		2009
Volume:		10
Issue:		4
Page Number:		295 - 300
DOI:		10.3816/CLC.2009.n.041
ISSN/ISBN:		1938-0690 (Electronic) 1525-7304 (Linking)
Abstract:		"Because of the poor results observed after platinum-based first-line chemotherapy, research on new strategies for second-line treatment of advanced non-small-cell lung cancer (NSCLC) is warranted. Current research focuses on the development of new agents and the assessment of a combination of therapies, especially those with different mechanisms of action. PM02734 (elisidepsin, Irvalec) is a compound related to Kahalalide F (KF), a moderately soluble marine product that belongs to a family of dehydro aminobutyric acid-containing peptides isolated from the herbivorous marine mollusk Elysia rufescens. Preclinical and clinical studies showed that KF induces strong cytotoxic activity against different solid tumors, including NSCLC, particularly in patients with squamous histology; in fact, almost 40% of patients treated in the second line were still alive at 1 year after beginning treatment with KF. Analysis of data collected during clinical development has revealed that KF has a predictable and manageable toxicity profile. The toxicities most commonly associated with KF are generally transient and mild or moderate. The absence of hematologic toxicity and cumulative toxic effects suggests that KF may be suitable for combination trials with other anticancer agents. The development of KF could stopped because of the unavailability of a natural source of the compound. PM02734 is a closely related derivative of KF with similar activity and characteristics. Herein, we summarize the studies of PM02734 and future clinical perspectives"
Keywords:		"Antineoplastic Agents/adverse effects/chemistry/pharmacology/*therapeutic use Carcinoma, Non-Small-Cell Lung/*drug therapy Depsipeptides/adverse effects/chemistry/pharmacology/*therapeutic use Humans Injections, Intravenous Lung Neoplasms/*drug therapy Mo;"
Notes:		"MedlineProvencio, Mariano Sanchez, Antonio Gasent, Joan Gomez, Patricia Rosell, Rafael eng Review 2009/07/28 Clin Lung Cancer. 2009 Jul; 10(4):295-300. doi: 10.3816/CLC.2009.n.041"