| Title: | Composition and antimicrobial activity of the essential oils of Laserpitium latifolium L. and L. ochridanum Micevski (Apiaceae) |
| Author(s): | Popovic VB; Petrovic SD; Milenkovic MT; Drobac MM; Couladis MA; Niketic MS; |
| Address: | "University of Belgrade, Faculty of Pharmacy, Department of Pharmacognosy, V. Stepe 450, RS-11221 Belgrade (phone: +381-11-3951319; fax: +381-11-3972840); Ghent University, Faculty of Science, Laboratory for Organic and Bio-organic Synthesis, Department of Organic and Macromolecular Chemistry, Krijgslaan 281 S4, BE-9000 Ghent, (phone: +32-9-2644476; fax: +32-9-2644998). Visnja.Popovic@UGent.be, visnjap@pharmacy.bg.ac.rs" |
| ISSN/ISBN: | 1612-1880 (Electronic) 1612-1872 (Linking) |
| Abstract: | "The chemical composition and antimicrobial activity of essential oils of Laserpitium latifolium and L. ochridanum were investigated. The essential oils were isolated by steam distillation and characterized by GC-FID and GC/MS analyses. All essential oils were distinguished by high contents of monoterpenes, and alpha-pinene was the most abundant compound in the essential oils of L. latifolium underground parts and fruits (contents of 44.4 and 44.0%, resp.). The fruit essential oil was also rich in sabinene (26.8%). Regarding the L. ochridanum essential oils, the main constituents were limonene in the fruit oil (57.7%) and sabinene in the herb oil (25.9%). The antimicrobial activity of these essential oils as well as that of L. ochridanum underground parts, whose composition was reported previously, was tested by the broth-microdilution method against four Gram-positive and three Gram-negative bacteria and two Candida albicans strains. Except the L. latifolium underground-parts essential oil, the other investigated oils showed a high antimicrobial potential against Staphylococcus aureus, S. epidermidis, Micrococcus luteus, or Candida albicans (minimal inhibitory concentrations of 13.0-73.0 mug/ml), comparable to or even higher than that of thymol, which was used as reference compound" |
| Keywords: | "Anti-Infective Agents/*pharmacology Apiaceae/*chemistry Gas Chromatography-Mass Spectrometry Oils, Volatile/*chemistry/*pharmacology Antimicrobial activity Essential oils Laserpitium species;" |
| Notes: | "MedlinePopovic, Visnja B Petrovic, Silvana D Milenkovic, Marina T Drobac, Milica M Couladis, Maria A Niketic, Marjan S eng Research Support, Non-U.S. Gov't Switzerland 2015/02/03 Chem Biodivers. 2015 Jan; 12(1):170-7. doi: 10.1002/cbdv.201400127" |
