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Pediatr Res

Title:		Development of severe bronchopulmonary dysplasia is associated with alterations in fecal volatile organic compounds
Author(s):		Berkhout DJC; Niemarkt HJ; Benninga MA; Budding AE; van Kaam AH; Kramer BW; Pantophlet CM; van Weissenbruch MM; de Boer NKH; de Meij TGJ;
Address:		"Department of Pediatric Gastroenterology, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands. Neonatal Intensive Care Unit, Maxima Medical Center, Veldhoven, The Netherlands. Department of Microbiology, VU University Medical Center, Amsterdam, The Netherlands. Neonatal Intensive Care Unit, Emma Children's Hospital/Academic Medical Center, Amsterdam, The Netherlands. Department of Pediatrics, Maastricht University Medical Center, Maastricht, The Netherlands. Department of Pediatric Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands. Neonatal Intensive Care Unit, VU University Medical Center, Amsterdam, The Netherlands. Department of Gastroenterology and Hepatology, VU University Medical Center, Amsterdam, The Netherlands"
Journal Title:		Pediatr Res
Year:		2018
Volume:		20171122
Issue:		2
Page Number:		412 - 419
DOI:		10.1038/pr.2017.268
ISSN/ISBN:		1530-0447 (Electronic) 0031-3998 (Linking)
Abstract:		"BackgroundThe aim of this study was to evaluate the potential of fecal volatile organic compounds (VOCs), obtained by means of an electronic nose device (Cyranose 320), as early non-invasive biomarker for BPD.MethodsIn this nested case-control study performed at three Neonatal Intensive Care Units, fecal samples obtained at postnatal age of 7, 14, 21, and 28 days from preterm infants with severe bronchopulmonary dysplasia (BPD) were compared with fecal VOC profiles from matched controls. Microbiota analysis was performed by means of IS-pro technique on fecal samples collected at 28 days postnatally.ResultsVOC profiles of infants developing severe BPD (n=15) could be discriminated from matched controls (n=15) at postnatal age of 14 days (area under the curve (+/-95% confidence interval), P-value, sensitivity, specificity; 0.72 (0.54-0.90), 0.040, 60.0%, 73.3%), 21 days (0.71 (0.52-0.90), 0.049, 66.7%, 73.3%) and 28 days (0.77 (0.59-0.96), 0.017, 69.2%, 69.2%) but not at 7 days. Intestinal microbiota did not differ between BPD subjects and controls.ConclusionFecal VOC profiles of infants developing BPD could be differentiated from controls at postnatal day 14, 21, and 28. VOC differences could not be directed to intestinal microbiota alterations but presumably reflect local and systemic metabolic and inflammatory pathways associated with BPD"
Keywords:		"Biomarkers Bronchopulmonary Dysplasia/*diagnosis/metabolism Case-Control Studies *Electronic Nose Feces/*chemistry Female Gastrointestinal Microbiome Humans Infant, Newborn Infant, Premature Intensive Care Units, Neonatal Male Sensitivity and Specificity;"
Notes:		"MedlineBerkhout, Daniel J C Niemarkt, Hendrik J Benninga, Marc A Budding, Andries E van Kaam, Anton H Kramer, Boris W Pantophlet, Charlene M van Weissenbruch, Mirjam M de Boer, Nanne K H de Meij, Tim G J eng Research Support, Non-U.S. Gov't 2017/10/21 Pediatr Res. 2018 Feb; 83(2):412-419. doi: 10.1038/pr.2017.268. Epub 2017 Nov 22"