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Cell Host Microbe

Title:		Apolipoprotein B Is an innate barrier against invasive Staphylococcus aureus infection
Author(s):		Peterson MM; Mack JL; Hall PR; Alsup AA; Alexander SM; Sully EK; Sawires YS; Cheung AL; Otto M; Gresham HD;
Address:		"Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA"
Journal Title:		Cell Host Microbe
Year:		2008
Volume:		4
Issue:		6
Page Number:		555 - 566
DOI:		10.1016/j.chom.2008.10.001
ISSN/ISBN:		1934-6069 (Electronic) 1931-3128 (Print) 1931-3128 (Linking)
Abstract:		"Staphylococcus aureus is both a colonizer of humans and a cause of severe invasive infections. Although the genetic basis for phenotype switching from colonizing to invasive has received significant study, knowledge of host factors that antagonize the switch is limited. We show that VLDL and LDL lipoproteins interfere with this switch by antagonizing the S. aureus agr quorum-sensing system that upregulates genes required for invasive infection. The mechanism of antagonism entails binding of the major structural protein of these lipoproteins, apolipoprotein B, to an S. aureus autoinducing pheromone, preventing attachment of this pheromone to the bacteria and subsequent signaling through its receptor, AgrC. Mice deficient in plasma apolipoprotein B, either genetically or pharmacologically, are more susceptible to invasive agr+ bacterial infection, but not to infection with an agr deletion mutant. Therefore, apolipoprotein B at homeostatic levels in blood is an essential innate defense effector against invasive S. aureus infection"
Keywords:		"Animals Apolipoproteins B/deficiency/*immunology/*metabolism Bacterial Proteins/genetics/metabolism Body Weight Carrier State/microbiology Gene Deletion Humans Lung/microbiology Mice Mice, Knockout Pheromones/metabolism Protein Binding Protein Kinases/met;"
Notes:		"MedlinePeterson, M Michal Mack, Jessica L Hall, Pamela R Alsup, Anny A Alexander, Susan M Sully, Erin K Sawires, Youhanna S Cheung, Ambrose L Otto, Michael Gresham, Hattie D eng R01 AI037142/AI/NIAID NIH HHS/ R01 AI064926/AI/NIAID NIH HHS/ AI 47441/AI/NIAID NIH HHS/ R01 AI064926-04/AI/NIAID NIH HHS/ R01 AI064926-03/AI/NIAID NIH HHS/ R01 AI047441/AI/NIAID NIH HHS/ R01 AI064926-01/AI/NIAID NIH HHS/ T32 AI007538/AI/NIAID NIH HHS/ R01 AI064926-02/AI/NIAID NIH HHS/ AI 37142/AI/NIAID NIH HHS/ AI-064926/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural 2008/12/10 Cell Host Microbe. 2008 Dec 11; 4(6):555-66. doi: 10.1016/j.chom.2008.10.001"