| Title: | Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans |
| Author(s): | Peng JY; Liu X; Zeng XT; Hao Y; Zhang JH; Li Q; Tong XJ; |
| Address: | "School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China; Lingang Laboratory, Shanghai 200031, China. Songjiang Institute and Songjiang Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China; Center for Brain Science, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; Department of Anatomy and Physiology, Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health in Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: tongxj@shanghaitech.edu.cn" |
| DOI: | 10.1016/j.celrep.2023.112598 |
| Abstract: | "Age-associated neurodegenerative disorders such as Parkinson's and Alzheimer's diseases are mainly caused by protein aggregation. The etiologies of these neurodegenerative diseases share a chemical environment. However, how chemical cues modulate neurodegeneration remains unclear. Here, we found that in Caenorhabditis elegans, exposure to pheromones in the L1 stage accelerates neurodegeneration in adults. Perception of pheromones ascr#3 and ascr#10 is mediated by chemosensory neurons ASK and ASI. ascr#3 perceived by G protein-coupled receptor (GPCR) DAF-38 in ASK activates glutamatergic transmission into AIA interneurons. ascr#10 perceived by GPCR STR-2 in ASI activates the secretion of neuropeptide NLP-1, which binds to the NPR-11 receptor in AIA. Activation of both ASI and ASK is required and sufficient to remodel neurodevelopment via AIA, which triggers insulin-like signaling and inhibits autophagy in adult neurons non-cell-autonomously. Our work reveals how pheromone perception at the early developmental stage modulates neurodegeneration in adults and provides insights into how the external environment impacts neurodegenerative diseases" |
| Keywords: | Animals *Caenorhabditis elegans/metabolism Signal Transduction Pheromones/metabolism *Caenorhabditis elegans Proteins/metabolism Insulin/metabolism Perception CP: Neuroscience autophagy early development insulin signaling neurodegeneration pheromones;neuroscience; |
| Notes: | "MedlinePeng, Jing-Yi Liu, Xuqing Zeng, Xian-Ting Hao, Yue Zhang, Jia-Hui Li, Qian Tong, Xia-Jing eng 2023/06/08 Cell Rep. 2023 Jun 27; 42(6):112598. doi: 10.1016/j.celrep.2023.112598. Epub 2023 Jun 7" |
