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Curr Opin Microbiol

Title:		Horizontal gene transfer and the genomics of enterococcal antibiotic resistance
Author(s):		Palmer KL; Kos VN; Gilmore MS;
Address:		"Departments of Ophthalmology, and Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USA"
Journal Title:		Curr Opin Microbiol
Year:		2010
Volume:		20100915
Issue:		5
Page Number:		632 - 639
DOI:		10.1016/j.mib.2010.08.004
ISSN/ISBN:		1879-0364 (Electronic) 1369-5274 (Print) 1369-5274 (Linking)
Abstract:		"Enterococci are Gram-positive bacteria that normally colonize gastrointestinal tracts of humans and animals. They are of growing concern because of their ability to cause antibiotic resistant hospital infections. Antibiotic resistance has been acquired, and has disseminated throughout enterococci, via horizontal transfer of mobile genetic elements. This transmission has been mediated mainly by conjugative plasmids of the pheromone-responsive and broad host range incompatibility group 18 type. Genome sequencing is revealing the extent of diversity of these and other mobile elements in enterococci, as well as the extent of recombination and rearrangement resulting in new phenotypes. Pheromone-responsive plasmids were recently shown to promote genome plasticity in antibiotic resistant Enterococcus faecalis, and their involvement has been implicated in E. faecium as well. Further, incompatibility group 18 plasmids have recently played an important role in mediating transfer of vancomycin resistance from enterococci to methicillin-resistant strains of S. aureus"
Keywords:		"Anti-Bacterial Agents/pharmacology *Drug Resistance, Multiple, Bacterial Enterococcus faecalis/*genetics/pathogenicity *Gene Transfer, Horizontal Genome, Bacterial Microbial Sensitivity Tests Pheromones/pharmacology Plasmids/*genetics Vancomycin Resistanc;"
Notes:		"MedlinePalmer, Kelli L Kos, Veronica N Gilmore, Michael S eng P01 AI083214/AI/NIAID NIH HHS/ R01 AI072360/AI/NIAID NIH HHS/ P01AI083214/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Review England 2010/09/15 Curr Opin Microbiol. 2010 Oct; 13(5):632-9. doi: 10.1016/j.mib.2010.08.004. Epub 2010 Sep 15"