« Previous Abstract"Behavioral characterization of attractin, a water-borne peptide pheromone in the genus aplysia"    Next AbstractExploring a public database to evaluate consumer preference and aroma profile of lager beers by comprehensive two-dimensional gas chromatography and partial least squares regression discriminant analysis »

Colloids Surf B Biointerfaces

Title:		Cyclodextrins as an encapsulation molecular strategy for volatile organic compounds- Pharmaceutical applications
Author(s):		Paiva-Santos AC; Ferreira L; Peixoto D; Silva F; Soares MJ; Zeinali M; Zafar H; Mascarenhas-Melo F; Raza F; Mazzola PG; Veiga F;
Address:		"Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal. Electronic address: acsantos@ff.uc.pt. Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal; REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal. Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Research and Development Unit, Daana Pharma Co, Tabriz, Iran. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: faisalraza@sjtu.edu.cn. Faculty of Pharmaceutical Sciences, University of Campinas, Campinas, SP, Brazil"
Journal Title:		Colloids Surf B Biointerfaces
Year:		2022
Volume:		20220805
Issue:
Page Number:		112758 -
DOI:		10.1016/j.colsurfb.2022.112758
ISSN/ISBN:		1873-4367 (Electronic) 0927-7765 (Linking)
Abstract:		"The use of essential oils has gained importance due to their wide range of biological properties. Essential oils comprise a complex mixture of volatile organic compounds (VOCs), so the study of VOCs as active pharmaceutical ingredients is often more precise and fruitful. VOCs are natural origin molecules that constitute a sustainable alternative to synthetic drugs due to their important therapeutic value. However, VOCs possess poor solubility in aqueous solutions, high volatility, and, consequently, low stability and bioavailability, limiting VOC handling in industry and their potential use in therapeutics, despite their promising biological properties. Thereby, cyclodextrins (CDs) have emerged as suitable carriers of VOCs, giving rise to so-called VOC/CD inclusion complexes. CDs constitute an inexpensive viable solution for encapsulating VOCs to improve their properties, namely their apparent solubility and stability toward pH, light, and temperature. This review provides a conceptual framework of several VOC/CD inclusion complexes developed. In addition, the most exploited preparation techniques and their influence on the values of encapsulation efficiency and formation constant (K(f)) are highlighted. The most recent in vitro or in vivo biological experiments regarding VOC/CD inclusion complexes in the development of pharmaceutical products are also presented. Finally, the toxicological, and regulatory aspects are discussed"
Keywords:		"Complex Mixtures *Cyclodextrins/chemistry *Oils, Volatile/chemistry Pharmaceutical Preparations Solubility *Synthetic Drugs *Volatile Organic Compounds/chemistry Cyclodextrin Encapsulation efficiency Essential oil Formation constant Inclusion complex Vola;"
Notes:		"MedlinePaiva-Santos, Ana Claudia Ferreira, Laura Peixoto, Diana Silva, Fernando Soares, Maria Joao Zeinali, Mahdi Zafar, Hajra Mascarenhas-Melo, Filipa Raza, Faisal Mazzola, Priscila Gava Veiga, Francisco eng Review Netherlands 2022/08/13 Colloids Surf B Biointerfaces. 2022 Oct; 218:112758. doi: 10.1016/j.colsurfb.2022.112758. Epub 2022 Aug 5"