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Commun Biol

Title:		Cuticular hydrocarbons are associated with mating success and insecticide resistance in malaria vectors
Author(s):		Adams KL; Sawadogo SP; Nignan C; Niang A; Paton DG; Robert Shaw W; South A; Wang J; Itoe MA; Werling K; Dabire RK; Diabate A; Catteruccia F;
Address:		"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Medical Biology and Public Health, Institut de Recherche en Science de la Sante (IRSS), Bobo-Dioulasso, Burkina Faso. Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA. Harvard Center for Mass Spectrometry, Harvard University, Cambridge, MA, USA. Department of Entomology, Pennsylvania State University, State College, PA, USA. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. fcatter@hsph.harvard.edu"
Journal Title:		Commun Biol
Year:		2021
Volume:		20210726
Issue:		1
Page Number:		911 -
DOI:		10.1038/s42003-021-02434-1
ISSN/ISBN:		2399-3642 (Electronic) 2399-3642 (Linking)
Abstract:		"Anopheles coluzzii females, important malaria vectors in Africa, mate only once in their lifetime. Mating occurs in aerial swarms with a high male-to-female ratio, where traits underlying male mating success are largely unknown. Here, we investigated whether cuticular hydrocarbons (CHCs) influence mating success in natural mating swarms in Burkina Faso. As insecticides are widely used in this area for malaria control, we also determined whether CHCs affect insecticide resistance levels. We find that mated males have higher CHC abundance than unmated controls, suggesting CHCs could be determinants of mating success. Additionally, mated males have higher insecticide resistance under pyrethroid challenge, and we show a link between resistance intensity and CHC abundance. Taken together, our results suggest that CHC abundance may be subject to sexual selection in addition to selection by insecticide pressure. This has implications for insecticide resistance management, as these traits may be sustained in the population due to their benefits in mating even in the absence of insecticides"
Keywords:		Animals Anopheles/drug effects/*physiology Burkina Faso Epidermis/chemistry Hydrocarbons/*pharmacology *Insecticide Resistance Insecticides/adverse effects Malaria Mosquito Vectors/drug effects/*physiology Pheromones/*pharmacology Pyrethrins/adverse effec;
Notes:		"MedlineAdams, Kelsey L Sawadogo, Simon P Nignan, Charles Niang, Abdoulaye Paton, Douglas G Robert Shaw, W South, Adam Wang, Jennifer Itoe, Maurice A Werling, Kristine Dabire, Roch K Diabate, Abdoulaye Catteruccia, Flaminia eng R01 AI104956/AI/NIAID NIH HHS/ R01 AI124165/AI/NIAID NIH HHS/ HHMI/Howard Hughes Medical Institute/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2021/07/28 Commun Biol. 2021 Jul 26; 4(1):911. doi: 10.1038/s42003-021-02434-1"