| Title: | Inhibition of pathogenicity of the rice blast fungus by Saccharomyces cerevisiae alpha-factor |
| Author(s): | Beckerman JL; Naider F; Ebbole DJ; |
| Address: | "Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX 77843-2132, USA" |
| DOI: | 10.1126/science.276.5315.1116 |
| ISSN/ISBN: | 0036-8075 (Print) 0036-8075 (Linking) |
| Abstract: | "Magnaporthe grisea is a fungal pathogen with two mating types, MAT1-1 and MAT1-2, that forms a specialized cell necessary for pathogenesis, the appressorium. Saccharomyces cerevisiae alpha-factor pheromone blocked appressorium formation in a mating type-specific manner and protected plants from infection by MAT1-2 strains. Experiments with alpha-factor analogs suggest that the observed activity is due to a specific interaction of alpha-factor with an M. grisea receptor. Culture filtrates of a MAT1-1 strain contained an activity that inhibited appressorium formation of mating type MAT1-2 strains. These findings provide evidence that a pheromone response pathway exists in M. grisea that can be exploited for plant protection" |
| Keywords: | "Amino Acid Sequence Ascomycota/cytology/pathogenicity/*physiology Crosses, Genetic Cyclic AMP/pharmacology Hordeum/microbiology Mating Factor Molecular Sequence Data Oryza/microbiology Peptides/metabolism/*pharmacology Pheromones/metabolism/*pharmacology;" |
| Notes: | "MedlineBeckerman, J L Naider, F Ebbole, D J eng GM22086/GM/NIGMS NIH HHS/ R29GM47977/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1997/05/16 Science. 1997 May 16; 276(5315):1116-9. doi: 10.1126/science.276.5315.1116" |
