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Cell Rep

Title:		Circuitry Rewiring Directly Couples Competence to Predation in the Gut Dweller Streptococcus salivarius
Author(s):		Mignolet J; Fontaine L; Sass A; Nannan C; Mahillon J; Coenye T; Hols P;
Address:		"Biochemistry, Biophysics, and Genetics of Microorganisms (BBGM), Institute of Life Sciences, Universite catholique de Louvain, 1348 Louvain-la-Neuve, Belgium. Electronic address: johann.mignolet@uclouvain.be. Biochemistry, Biophysics, and Genetics of Microorganisms (BBGM), Institute of Life Sciences, Universite catholique de Louvain, 1348 Louvain-la-Neuve, Belgium. Laboratory of Pharmaceutical Microbiology, Ghent University, 9000 Ghent, Belgium. Laboratory of Food and Environmental Microbiology, Earth and Life Institute, Universite catholique de Louvain, 1348 Louvain-la-Neuve, Belgium. Biochemistry, Biophysics, and Genetics of Microorganisms (BBGM), Institute of Life Sciences, Universite catholique de Louvain, 1348 Louvain-la-Neuve, Belgium. Electronic address: pascal.hols@uclouvain.be"
Journal Title:		Cell Rep
Year:		2018
Volume:		22
Issue:		7
Page Number:		1627 - 1638
DOI:		10.1016/j.celrep.2018.01.055
ISSN/ISBN:		2211-1247 (Electronic)
Abstract:		"Small distortions in transcriptional networks might lead to drastic phenotypical changes, especially in cellular developmental programs such as competence for natural transformation. Here, we report a pervasive circuitry rewiring for competence and predation interplay in commensal streptococci. Canonically, in streptococci paradigms such as Streptococcus pneumoniae and Streptococcus mutans, the pheromone-based two-component system BlpRH is a central node that orchestrates the production of antimicrobial compounds (bacteriocins) and incorporates signal from the competence activation cascade. However, the human commensal Streptococcus salivarius does not contain a functional BlpRH pair, while the competence signaling system ComRS directly couples bacteriocin production and competence commitment. This network shortcut might underlie an optimal adaptation against microbial competitors and explain the high prevalence of S. salivarius in the human digestive tract. Moreover, the broad spectrum of bacteriocin activity against pathogenic bacteria showcases the commensal and genetically tractable S. salivarius species as a user-friendly model for competence and bacterial predation"
Keywords:		"Amino Acid Sequence Bacterial Proteins/chemistry/metabolism Bacterial Translocation Bacteriocins/metabolism Base Sequence Gastrointestinal Tract/*microbiology Gene Regulatory Networks Genes, Bacterial Promoter Regions, Genetic/genetics Regulon/genetics Sp;"
Notes:		"MedlineMignolet, Johann Fontaine, Laetitia Sass, Andrea Nannan, Catherine Mahillon, Jacques Coenye, Tom Hols, Pascal eng Research Support, Non-U.S. Gov't 2018/02/15 Cell Rep. 2018 Feb 13; 22(7):1627-1638. doi: 10.1016/j.celrep.2018.01.055"